Journal Article

PUBDB-2022-04575

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Phase Behavior and Miscibility in Two-Component Glycolipid Monolayers

Mukhina, T.Extern* ; Brezesinski, G.Extern* ; Schneck, E. (Corresponding author)

2022
Soc. Washington, DC

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Please use a persistent id in citations: doi:10.1021/acs.jpcb.2c05016  doi:10.3204/PUBDB-2022-04575

Abstract: Glycolipids are known to be involved in the formation of ordered functional domains in biological membranes. Since the structural characterization of such domains is difficult, most studies have so far dealt with lipid mixtures containing only one glycolipid component at a time, although biological membranes usually contain several glycolipid species, which can result in more complex structures and phase behavior. Here, we combine classical isotherm measurements with surface-sensitive grazingincidence X-ray diffraction to investigate the phase behavior and miscibility in Langmuir monolayers of binary glycolipid mixtures. We find that the phase behavior has a subtle dependence on the saccharide headgroup chemistry. For compatible chemistries, molecular superlattice structures formed by one of the glycolipid species are conserved and can host foreign glycolipids up to a defined stoichiometry. In contrast, for sterically incompatible saccharide chemistries, the superlattice is lost even if both species are able to form such structures in their pure forms. Our results suggest that related phenomena may play important roles also in biological contexts.

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
2. FS-Proposal: I-20190719 (I-20190719) (I-20190719)
3. FS-Proposal: I-20191281 (I-20191281) (I-20191281)
4. FS-Proposal: I-20200672 (I-20200672) (I-20200672)
5. FS-Proposal: I-20210377 (I-20210377) (I-20210377)

Experiment(s):

1. PETRA Beamline P08 (PETRA III)

Appears in the scientific report 2022

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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