Dissertation / PhD Thesis

PUBDB-2018-05649

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Macromolecular pHPMA-Based Nanoparticles for Solid Tumor Targeting: Behavior in Protein Environment

Zhang, X. (Corresponding author)Extern* ; Gerland, U. (Thesis advisor)

2018

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Please use a persistent id in citations: doi:10.3204/PUBDB-2018-05649

Abstract: Nanoparticles(NPs) formed by self-assembly of amphiphilic poly(N-(2-hydroxypropyl)-methacrylamide) copolymers are potential drug carriers for solid tumor treatment. In this work, their structure and behavior are investigated in solutionsof human serum albumin (HSA) in phosphate buffered saline. It is found, that the interaction between HSA and the NPs neither alters the size nor the structure of the NPs. Thus, the drug delivery is not hindered by the presence of HSA.

Note: Dissertation, Technische Universität München, 2018

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Contributing Institute(s):

1. EMBL-User (EMBL-User)

Research Program(s):

1. 6G3 - PETRA III (POF3-622) (POF3-622)

Experiment(s):

1. PETRA Beamline P12 (PETRA III)

Appears in the scientific report 2018

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Database coverage:

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