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| Home > Publications database > Effects of X-ray Radiation on Zebrafish Embryos |
| Bachelor Thesis | PUBDB-2025-04705 |
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2025
Technische Hochschule Wildau
Wildau
Abstract: The research on radiation therapy for cancer treatment is of the highest importance to society, ascancer is a leading cause of death. Conventional radiation therapy is conducted with X-rayradiation; however, new treatments are being researched using other types of ionizing radiationto deliver radiation doses more precisely to tumours while sparing healthy tissue and overcomingradioresistant cancers. The primary approach to examine the radiobiological effects on the levelof entire organisms is to use animal models such as Zebrafish embryos. Zebrafish embryos area high-throughput model for studying developmental and environmental biology. Zebrafish arerelatively easy to care for and maintain.Most importantly, Zebrafish develop most of their organs within five days, thus enabling a completedevelopmental assessment within this timeframe. Parameters that can signify radiation damageare spinal curvature, pericardial edema, body size, eye diameter and survival rate. With anincrease in irradiation dose applied to the embryo, these morphological endpoints change; spinalcurvature and pericardial edema increase in number and severity, while body size and eye diameterdecrease. The morphological deformities increase after 8Gy X-ray irradiation, up to 15Gy, afterwhich mortality rises, until 20Gy, at which point embryo mortality reaches 100%.These results can aid in comparing other types of irradiation, as the handling of the Zebrafish embryosand the expected outcomes of conventional X-ray irradiation are
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