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@MASTERSTHESIS{Schulze:640002,
      author       = {Schulze, Charlotte Amelie},
      othercontributors = {Frohme, Marcus and Grebinyk, Anna},
      title        = {{E}ffects of {X}-ray {R}adiation on {Z}ebrafish {E}mbryos},
      school       = {Technische Hochschule Wildau},
      type         = {Bachelorarbeit},
      address      = {Wildau},
      publisher    = {Technische Hochschule Wildau},
      reportid     = {PUBDB-2025-04705},
      pages        = {44},
      year         = {2025},
      note         = {Bachelorarbeit, Technische Hochschule Wildau, 2025},
      abstract     = {The research on radiation therapy for cancer treatment is
                      of the highest importance to society, ascancer is a leading
                      cause of death. Conventional radiation therapy is conducted
                      with X-rayradiation; however, new treatments are being
                      researched using other types of ionizing radiationto deliver
                      radiation doses more precisely to tumours while sparing
                      healthy tissue and overcomingradioresistant cancers. The
                      primary approach to examine the radiobiological effects on
                      the levelof entire organisms is to use animal models such as
                      Zebrafish embryos. Zebrafish embryos area high-throughput
                      model for studying developmental and environmental biology.
                      Zebrafish arerelatively easy to care for and maintain.Most
                      importantly, Zebrafish develop most of their organs within
                      five days, thus enabling a completedevelopmental assessment
                      within this timeframe. Parameters that can signify radiation
                      damageare spinal curvature, pericardial edema, body size,
                      eye diameter and survival rate. With anincrease in
                      irradiation dose applied to the embryo, these morphological
                      endpoints change; spinalcurvature and pericardial edema
                      increase in number and severity, while body size and eye
                      diameterdecrease. The morphological deformities increase
                      after 8Gy X-ray irradiation, up to 15Gy, afterwhich
                      mortality rises, until 20Gy, at which point embryo mortality
                      reaches $100\%.These$ results can aid in comparing other
                      types of irradiation, as the handling of the Zebrafish
                      embryosand the expected outcomes of conventional X-ray
                      irradiation are},
      cin          = {$Z_PITZ$},
      cid          = {$I:(DE-H253)Z_PITZ-20210408$},
      pnm          = {621 - Accelerator Research and Development (POF4-621)},
      pid          = {G:(DE-HGF)POF4-621},
      experiment   = {EXP:(DE-H253)PITZ-20150101},
      typ          = {PUB:(DE-HGF)2},
      url          = {https://bib-pubdb1.desy.de/record/640002},
}