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@ARTICLE{Wojdyla:89292,
author = {Wojdyla, J. A. and Manolaridis, I. and Snijder, E. J. and
Gorbalenya, A. E. and Coutard, B. and Piotrowski, Y. and
Hilgenfeld, R. and Tucker, P. A. and DESY},
title = {{S}tructure of the {X} ({ADRP}) domain of nsp3 from feline
coronavirus},
journal = {Acta crystallographica / D},
volume = {65},
issn = {0907-4449},
address = {Copenhagen},
publisher = {Munksgaard},
reportid = {PHPPUBDB-12653},
pages = {1292-1300},
year = {2009},
note = {© International Union of Crystallography; Post referee
fulltext in progress 2},
abstract = {The structure of the X (or ADRP) domain of a pathogenic
variant of feline coronavirus (FCoV) has been determined in
tetragonal and cubic crystal forms to 3.1 and 2.2 A
resolution, respectively. In the tetragonal crystal form,
glycerol-3-phosphate was observed in the ADP-ribose-binding
site. Both crystal forms contained large solvent channels
and had a solvent content of higher than $70\%.$ Only very
weak binding of this domain to ADP-ribose was detected in
vitro. However, the structure with ADP-ribose bound was
determined in the cubic crystal form at 3.9 A resolution.
The structure of the FCoV X domain had the expected
macro-domain fold and is the first structure of this domain
from a coronavirus belonging to subgroup 1a.},
keywords = {Adenosine Diphosphate Ribose: chemistry / Adenosine
Diphosphate Ribose: metabolism / Amino Acid Sequence /
Binding Sites / Coronavirus, Feline: enzymology /
Crystallography, X-Ray / Glycerophosphates: chemistry /
Glycerophosphates: metabolism / Molecular Sequence Data /
Protein Binding / Protein Interaction Domains and Motifs /
RNA Replicase: chemistry / Sequence Alignment / Sequence
Homology, Amino Acid / Viral Nonstructural Proteins:
chemistry / Glycerophosphates (NLM Chemicals) / Viral
Nonstructural Proteins (NLM Chemicals) / Adenosine
Diphosphate Ribose (NLM Chemicals) / alpha-glycerophosphoric
acid (NLM Chemicals) / RNA Replicase (NLM Chemicals)},
cin = {EMBL(-2012)},
ddc = {570},
cid = {$I:(DE-H253)EMBL_-2012_-20130307$},
pnm = {FS Beamline without reference (POF1-550)},
pid = {G:(DE-H253)POF1-No-Ref-20130405},
experiment = {EXP:(DE-H253)Unknown-BL-20150101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:19966415},
UT = {WOS:000271912500007},
doi = {10.1107/S0907444909040074},
url = {https://bib-pubdb1.desy.de/record/89292},
}