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@INPROCEEDINGS{Tarakci:643491,
author = {Tarakci, Elif},
title = {{M}ethod {V}alidation to {E}valuate the {E}ffects of
{X}-{R}ay{R}adiation on {Z}ebrafish {E}mbryo {D}evelopment},
school = {DESY},
reportid = {PUBDB-2026-00238},
year = {2025},
abstract = {Zebrafish (Danio rerio) embryos are a well-recognized model
organism for assessing toxicological effects due to their
approximately $70\%$ genetic similarity to humans, rapid
development, and transparent embryonic stages. Investigating
toxic effects in zebrafish embryos provides valuable
insights into effects of cancer treatment on normal tissue.
In this project, we focus on the use of X-ray radiation as a
toxicity inducer to identify potential developmental
disruptions in zebrafish embryos. The project is conducted
within the $R\&D$ platform FLASHlab@PITZ, a collaboration
between the Photo Injector Test Facility at DESY in Zeuthen
(PITZ), Technical University of Applied Sciences Wildau,
Charité – Universitätsmedizin Berlin, Max-Delbrück
Center (MDC) in the field of radiation biology and radiation
therapy. The initial phase focuses on optimizing and
validating embryo handling and toxicity assessment methods,
serving as foundation for future studies comparing
ultra-high dose rate (UHDR) electron radiation with
conventional X-ray radiation. The ultimate goal is to
advance radiation-based therapies and validate the potential
for healthy tissue-sparing effects with UHDR electron
radiation.},
month = {Sep},
date = {2025-09-24},
organization = {DGMP, berlin (Germany), 24 Sep 2025 -
27 Sep 2025},
cin = {$Z_PITZ$},
cid = {$I:(DE-H253)Z_PITZ-20210408$},
pnm = {621 - Accelerator Research and Development (POF4-621)},
pid = {G:(DE-HGF)POF4-621},
experiment = {EXP:(DE-H253)PITZ-20150101},
typ = {PUB:(DE-HGF)24},
url = {https://bib-pubdb1.desy.de/record/643491},
}