TY  - EJOUR
AU  - Krabbes, Maria
AU  - Kampik, Vincent
AU  - Büttner, Mathilde
AU  - Kaysser, Leonard
AU  - Schneck, Emanuel
AU  - Shen, Chen
AU  - Woelk, Christian
TI  - Intrinsic structure of lipoplexes embedded in polyelectrolyte multilayers
M1  - PUBDB-2025-05594
PY  - 2025
AB  - The functionalization of surfaces with therapeutically applicable nucleic acid carriers provides promising strategies in biomedical research to develop therapies which focus on local nucleic acid delivery. One such approach is the embedding of lipoplexes (LPXs) in polysaccharide-based polyelectrolyte multilayers (PEMs). PEMs based on hyaluronic acid and chitosan lead to efficient embedding of customized LPX connected with good biological activity. However, although quantitative evaluation demonstrates LPX embedding, information on the embedded LPXs has been missing. In this study we used synchrotron-based grazing-incidence small angle x-ray scattering to investigate the effects of the change in the chemical environment caused by the embedding into PEMs on the LPX’s internal mesoscopic structure. While the lamellar character of the LPXs was preserved, the repeat distance was affected by the embedding into polysaccharide-based coatings.
LB  - PUB:(DE-HGF)25
DO  - DOI:10.1101/2025.10.10.681465
UR  - https://bib-pubdb1.desy.de/record/642745
ER  -