000642745 001__ 642745
000642745 005__ 20260112212241.0
000642745 0247_ $$2doi$$a10.1101/2025.10.10.681465
000642745 037__ $$aPUBDB-2025-05594
000642745 041__ $$aEnglish
000642745 1001_ $$0P:(DE-H253)PIP1111626$$aKrabbes, Maria$$b0
000642745 245__ $$aIntrinsic structure of lipoplexes embedded in polyelectrolyte multilayers
000642745 260__ $$c2025
000642745 3367_ $$0PUB:(DE-HGF)25$$2PUB:(DE-HGF)$$aPreprint$$bpreprint$$mpreprint$$s1768207178_2487190
000642745 3367_ $$2ORCID$$aWORKING_PAPER
000642745 3367_ $$028$$2EndNote$$aElectronic Article
000642745 3367_ $$2DRIVER$$apreprint
000642745 3367_ $$2BibTeX$$aARTICLE
000642745 3367_ $$2DataCite$$aOutput Types/Working Paper
000642745 520__ $$aThe functionalization of surfaces with therapeutically applicable nucleic acid carriers provides promising strategies in biomedical research to develop therapies which focus on local nucleic acid delivery. One such approach is the embedding of lipoplexes (LPXs) in polysaccharide-based polyelectrolyte multilayers (PEMs). PEMs based on hyaluronic acid and chitosan lead to efficient embedding of customized LPX connected with good biological activity. However, although quantitative evaluation demonstrates LPX embedding, information on the embedded LPXs has been missing. In this study we used synchrotron-based grazing-incidence small angle x-ray scattering to investigate the effects of the change in the chemical environment caused by the embedding into PEMs on the LPX’s internal mesoscopic structure. While the lamellar character of the LPXs was preserved, the repeat distance was affected by the embedding into polysaccharide-based coatings.
000642745 536__ $$0G:(DE-HGF)POF4-633$$a633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633)$$cPOF4-633$$fPOF IV$$x0
000642745 536__ $$0G:(DE-HGF)POF4-6G3$$a6G3 - PETRA III (DESY) (POF4-6G3)$$cPOF4-6G3$$fPOF IV$$x1
000642745 536__ $$0G:(GEPRIS)396823779$$aDFG project G:(GEPRIS)396823779 - Entwicklung von Lipoplex-beladenen Modelloberflächen für die in situ Transfektion im Bereich der Knochenregeneration (396823779)$$c396823779$$x2
000642745 536__ $$0G:(DE-H253)R-20240669$$aFS-Proposal: R-20240669 (R-20240669)$$cR-20240669$$x3
000642745 588__ $$aDataset connected to CrossRef
000642745 693__ $$0EXP:(DE-H253)P-P08-20150101$$1EXP:(DE-H253)PETRAIII-20150101$$6EXP:(DE-H253)P-P08-20150101$$aPETRA III$$fPETRA Beamline P08$$x0
000642745 7001_ $$0P:(DE-H253)PIP1111590$$aKampik, Vincent$$b1
000642745 7001_ $$aBüttner, Mathilde$$b2
000642745 7001_ $$aKaysser, Leonard$$b3
000642745 7001_ $$0P:(DE-H253)PIP1011036$$aSchneck, Emanuel$$b4
000642745 7001_ $$0P:(DE-H253)PIP1014115$$aShen, Chen$$b5
000642745 7001_ $$0P:(DE-H253)PIP1020591$$aWoelk, Christian$$b6$$eCorresponding author
000642745 773__ $$a10.1101/2025.10.10.681465
000642745 8564_ $$uhttps://bib-pubdb1.desy.de/record/642745/files/2025.10.10.681465v1.full.pdf$$yRestricted
000642745 8564_ $$uhttps://bib-pubdb1.desy.de/record/642745/files/2025.10.10.681465v1.full.pdf?subformat=pdfa$$xpdfa$$yRestricted
000642745 909CO $$ooai:bib-pubdb1.desy.de:642745$$pVDB
000642745 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1111626$$aExternal Institute$$b0$$kExtern
000642745 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1111590$$aExternal Institute$$b1$$kExtern
000642745 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1011036$$aExternal Institute$$b4$$kExtern
000642745 9101_ $$0I:(DE-588b)2008985-5$$6P:(DE-H253)PIP1014115$$aDeutsches Elektronen-Synchrotron$$b5$$kDESY
000642745 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1014115$$aExternal Institute$$b5$$kExtern
000642745 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1020591$$aExternal Institute$$b6$$kExtern
000642745 9131_ $$0G:(DE-HGF)POF4-633$$1G:(DE-HGF)POF4-630$$2G:(DE-HGF)POF4-600$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vLife Sciences – Building Blocks of Life: Structure and Function$$x0
000642745 9131_ $$0G:(DE-HGF)POF4-6G3$$1G:(DE-HGF)POF4-6G0$$2G:(DE-HGF)POF4-600$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bForschungsbereich Materie$$lGroßgeräte: Materie$$vPETRA III (DESY)$$x1
000642745 9141_ $$y2025
000642745 9201_ $$0I:(DE-H253)HAS-User-20120731$$kDOOR ; HAS-User$$lDOOR-User$$x0
000642745 9201_ $$0I:(DE-H253)FS-PETRA-D-20210408$$kFS-PETRA-D$$lPETRA-D$$x1
000642745 980__ $$apreprint
000642745 980__ $$aVDB
000642745 980__ $$aI:(DE-H253)HAS-User-20120731
000642745 980__ $$aI:(DE-H253)FS-PETRA-D-20210408
000642745 980__ $$aUNRESTRICTED