Contribution to a conference proceedings/Contribution to a book

PUBDB-2025-04988

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Structural Biomedical Two-Photon Microscopy Using a Sub-35 fs, High-Energy (>40 nJ), Pre-Chirp Managed Yb:Fiber Laser System

Edelmann, M.CFEL*Extern* ; Gevorgyan, S.Extern*XFEL.EU*EMBL* ; Pergament, M.CFEL*DESY* ; Betzel, C.Extern* ; Kärtner, F. X.CFEL*XFEL.EU*DESY*

2025
IEEE [Piscataway, NJ]
ISBN: 979-8-3315-1252-1

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Please use a persistent id in citations: doi:10.1109/CLEO/Europe-EQEC65582.2025.11109597

Abstract: Two-photon microscopy (2PM) is a vital imaging tool for modern life science [1]. As enabling technology, compact Yb:fiber lasers combined with novel labelling techniques have emerged as rapidly advancing sources for high-performance biomedical 2PM applications [2]. Here, we demonstrate a novel, highly-optimized Yb:fiber laser (YFL) design that uses simulation-guided nonlinear amplification to generate pulses with up to 40 nJ pulse energy at sub-35 fs duration for multimodal two-photon imaging of labelled mouse kidney and protein crystals.

Note: Literaturangaben;

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Contributing Institute(s):

1. Ultrafast Lasers & X-rays Division (FS-CFEL-2)

Research Program(s):

1. 631 - Matter – Dynamics, Mechanisms and Control (POF4-631) (POF4-631)

Experiment(s):

1. Experiments at CFEL

Appears in the scientific report 2025

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