TY  - JOUR
AU  - Kloskowski, Patrick
AU  - Neumann, Piotr
AU  - Berndt, Annette
AU  - Ficner, Ralf
TI  - Nucleotide-bound crystal structures of the SARS-CoV-2 helicase NSP13
JO  - Acta crystallographica / Section F
VL  - 81
IS  - 8
SN  - 1744-3091
CY  - Oxford [u.a.]
PB  - Blackwell
M1  - PUBDB-2025-04027
SP  - 338 - 347
PY  - 2025
N1  - Funding for this research was provided by the DeutscheForschungsgemeinschaft (Germany’s Excellence StrategyEXC 2067/1-390729940 to RF and grant No. INST186/1117 toRF).
AB  - Nucleotide-bound crystal structures of SARS-CoV-2 NSP13 in ADP- and ATP-bound states were resolved to 1.8 and 1.9 Å, respectively. The ADP-bound model captures a state immediately following ATP hydrolysis, with both ADP and orthophosphate still present in the active site. Further comparative analysis revealed that crystal packing influences NSP13 by stabilizing the nucleotide-binding site, underscoring the importance of accounting for these effects in structure-based drug design targeting NSP13.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1107/S2053230X25005266
UR  - https://bib-pubdb1.desy.de/record/638309
ER  -