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000638309 1001_ $$0P:(DE-HGF)0$$aKloskowski, Patrick$$b0
000638309 245__ $$aNucleotide-bound crystal structures of the SARS-CoV-2 helicase NSP13
000638309 260__ $$aOxford [u.a.]$$bBlackwell$$c2025
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000638309 500__ $$aFunding for this research was provided by the DeutscheForschungsgemeinschaft (Germany’s Excellence StrategyEXC 2067/1-390729940 to RF and grant No. INST186/1117 toRF).
000638309 520__ $$aNucleotide-bound crystal structures of SARS-CoV-2 NSP13 in ADP- and ATP-bound states were resolved to 1.8 and 1.9 Å, respectively. The ADP-bound model captures a state immediately following ATP hydrolysis, with both ADP and orthophosphate still present in the active site. Further comparative analysis revealed that crystal packing influences NSP13 by stabilizing the nucleotide-binding site, underscoring the importance of accounting for these effects in structure-based drug design targeting NSP13.
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000638309 7001_ $$aNeumann, Piotr$$b1
000638309 7001_ $$aBerndt, Annette$$b2
000638309 7001_ $$0P:(DE-H253)PIP1018222$$aFicner, Ralf$$b3$$eCorresponding author
000638309 773__ $$0PERI:(DE-600)2175956-X$$a10.1107/S2053230X25005266$$gVol. 81, no. 8, p. 338 - 347$$n8$$p338 - 347$$tActa crystallographica / Section F$$v81$$x1744-3091$$y2025
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