%0 Journal Article
%A Kloskowski, Patrick
%A Neumann, Piotr
%A Berndt, Annette
%A Ficner, Ralf
%T Nucleotide-bound crystal structures of the SARS-CoV-2 helicase NSP13
%J Acta crystallographica / Section F
%V 81
%N 8
%@ 1744-3091
%C Oxford [u.a.]
%I Blackwell
%M PUBDB-2025-04027
%P 338 - 347
%D 2025
%Z Funding for this research was provided by the DeutscheForschungsgemeinschaft (Germany’s Excellence StrategyEXC 2067/1-390729940 to RF and grant No. INST186/1117 toRF).
%X Nucleotide-bound crystal structures of SARS-CoV-2 NSP13 in ADP- and ATP-bound states were resolved to 1.8 and 1.9 Å, respectively. The ADP-bound model captures a state immediately following ATP hydrolysis, with both ADP and orthophosphate still present in the active site. Further comparative analysis revealed that crystal packing influences NSP13 by stabilizing the nucleotide-binding site, underscoring the importance of accounting for these effects in structure-based drug design targeting NSP13.
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1107/S2053230X25005266
%U https://bib-pubdb1.desy.de/record/638309