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@ARTICLE{Hoffmann:631516,
      author       = {Hoffmann, Patrick C. and Kim, Hyuntae and Obarska-Kosinska,
                      Agnieszka and Kreysing, Jan Philipp and Andino-Frydman, Eli
                      and Cruz-León, Sergio and Margiotta, Erica and Cernikova,
                      Lenka and Kosinski, Jan and Turoňová, Beata and Hummer,
                      Gerhard and Beck, Martin},
      title        = {{N}uclear pore permeability and fluid flow are modulated by
                      its dilation state},
      journal      = {Molecular cell},
      volume       = {85},
      number       = {3},
      issn         = {1097-2765},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {PUBDB-2025-02028},
      pages        = {537 - 554.e11},
      year         = {2025},
      abstract     = {Changing environmental conditions necessitate an immediate
                      cellular adaptation to ensure survival. Dictyostelium
                      discoideum, a bacteriovore slime mold present in the soil of
                      most terrestrial ecosystems, is known for its ability to
                      tolerate drastic changes in osmolarity. How the cells cope
                      with the resulting mechanical stress remains understudied.
                      Here we show that D. discoideum has extraordinarily
                      elaborate and resilient nuclear pores that serve as conduits
                      for massive fluid exchange between cytosol and nucleus. We
                      capitalize on the unique properties of D. discoideum cells
                      to quantify flow across the nuclear envelope that is
                      necessitated by changing nuclear size in response to osmotic
                      stress. Based on mathematical concepts adapted from
                      hydrodynamics, we conceptualize this phenomenon as porous
                      flow across nuclear pores. This type of fluid flow is
                      distinct from the canonically characterized modes of
                      nucleocytoplasmic transport, i.e. passive diffusion and
                      active nuclear transport, because of its dependence on
                      pressure. Our insights are relevant in any biological
                      condition that necessitates rapid nuclear size changes,
                      which includes metastasizing cancer cells squeezing through
                      constrictions, migrating cells and differentiating tissues.},
      cin          = {CSSB-EMBL-JK},
      ddc          = {610},
      cid          = {I:(DE-H253)CSSB-EMBL-JK-20210701},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39729993},
      doi          = {10.1016/j.molcel.2024.11.038},
      url          = {https://bib-pubdb1.desy.de/record/631516},
}