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| 001 | 626391 | ||
| 005 | 20250723105841.0 | ||
| 024 | 7 | _ | |a 10.1093/nar/gkaf065 |2 doi |
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| 100 | 1 | _ | |a Delaforge, Elise |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Allovalent scavenging of activation domains in the transcription factor ANAC013 gears transcriptional regulation |
| 260 | _ | _ | |a Oxford |c 2025 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Transcriptional regulation involves interactions between transcription factors, coregulators, and DNA. Intrinsic disorder is a major player in this regulation, but mechanisms driven by disorder remain elusive. Here, we address molecular communication within the stress-regulating Arabidopsis thaliana transcription factor ANAC013. Through high-throughput screening of ANAC013 for transcriptional activation activity, we identify three activation domains within its C-terminal intrinsically disordered region. Two of these overlap with acidic islands and form dynamic interactions with the DNA-binding domain and are released, not only upon binding of target promoter DNA, but also by nonspecific DNA. We show that independently of DNA binding, the RST (RCD--SRO--TAF4) domain of the negative regulator RCD1 (Radical-induced Cell Death1) scavenges the two acidic activation domains positioned vis-à-vis through allovalent binding, leading to dynamic occupation at enhanced affinity. We propose an allovalency model for transcriptional regulation, where sequentially close activation domains in both DNA-bound and DNA-free states allow for efficient regulation. The model is likely relevant for many transcription factor systems, explaining the functional advantage of carrying sequentially close activation domains. |
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| 700 | 1 | _ | |a Due, Amanda D |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Theisen, Frederik Friis |0 0000-0002-3412-4242 |b 2 |
| 700 | 1 | _ | |a Morffy, Nicolas |b 3 |
| 700 | 1 | _ | |a O’Shea, Charlotte |b 4 |
| 700 | 1 | _ | |a Blackledge, Martin |b 5 |
| 700 | 1 | _ | |a Strader, Lucia C |b 6 |
| 700 | 1 | _ | |a Skriver, Karen |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 700 | 1 | _ | |a Kragelund, Birthe B |0 P:(DE-HGF)0 |b 8 |e Corresponding author |
| 773 | _ | _ | |a 10.1093/nar/gkaf065 |g Vol. 53, no. 4, p. gkaf065 |0 PERI:(DE-600)2205588-5 |n 4 |p gkaf065 |t Nucleic acids symposium series |v 53 |y 2025 |x 0305-1048 |
| 856 | 4 | _ | |u https://academic.oup.com/nar/article/53/4/gkaf065/8008525 |
| 856 | 4 | _ | |u https://bib-pubdb1.desy.de/record/626391/files/Allovalent%20scavenging%20of%20activation%20domains%20in%20the%20transcription%20factor%20ANAC013%20gears%20transcriptional%20regulation.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://bib-pubdb1.desy.de/record/626391/files/Allovalent%20scavenging%20of%20activation%20domains%20in%20the%20transcription%20factor%20ANAC013%20gears%20transcriptional%20regulation.pdf?subformat=pdfa |x pdfa |y OpenAccess |
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