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000622934 1001_ $$aGolan, Nimrod$$b0
000622934 245__ $$aResilience and charge-dependent fibrillation of functional amyloid: Interactions of Pseudomonas biofilm-associated FapB and FapC amyloids
000622934 260__ $$aBethesda, MD$$bAmerican Soc. for Biochemistry and Molecular Biology$$c2025
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000622934 500__ $$aM. L. acknowledges research support from the Israel Science Foundation, Grant No. 2111/20, Israel, the Cure Alzheimer’s Fund, USA, the Forschungskooperation Niedersachsen–Israel, Volkswagenstiftung, No: 76251-4659/2022 (ZN 4042), Germany, and the Russell Berrie Nanotechnology Institue (RBNI), Israel.
000622934 520__ $$aFapC and FapB are biofilm-associated amyloids involved in the virulence of Pseudomonas and other bacteria. We herein demonstrate their exceptional thermal and chemical resilience, suggesting that their biofilm structures might withstand standard sterilization, thereby contributing to the persistence of Pseudomonas aeruginosa infections. Our findings also underscore the impact of environmental factors on functional amyloid in Pseudomonas (Fap) proteins, suggesting that orthologs in different Pseudomonas strains adapt to specific environments and roles. Challenging previous assumptions about a simple nucleation role for FapB in promoting FapC aggregation, the study shows a significant influence of FapC on FapB aggregation. The interaction between these FapB and FapC is intricate: FapB stabilizes FapC fibrils, while FapC slows down FapB fibrillation but can still serve as a cross-seeding template. This complex interplay is the key to understanding their roles in bacterial biofilms. Furthermore, the study highlights distinct differences between Fap and Escherichia coli's CsgA (curli) amyloid, where CsgB assumes a simple unidirectional role in nucleating CsgA fibrillation, emphasizing the importance of a comprehensive understanding of various amyloid systems. This knowledge is vital for developing effective intervention strategies against bacterial infections and leveraging the unique properties of these amyloids in technological applications such as novel bionanomaterials or protective coatings.
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000622934 7001_ $$00009-0005-9195-310X$$aParizat, Amit$$b1
000622934 7001_ $$aTabachnikov, Orly$$b2
000622934 7001_ $$aBarnea, Eilon$$b3
000622934 7001_ $$aOlsen, William P.$$b4
000622934 7001_ $$00000-0002-2918-8989$$aOtzen, Daniel E.$$b5
000622934 7001_ $$0P:(DE-H253)PIP1026961$$aLandau, Meytal$$b6$$eCorresponding author$$udesy
000622934 773__ $$0PERI:(DE-600)2141744-1$$a10.1016/j.jbc.2024.108096$$gVol. 301, no. 2, p. 108096 -$$n2$$p108096$$tJBC papers in press$$v301$$x0021-9258$$y2025
000622934 7870_ $$0PUBDB-2024-05651$$aGolan, Nimrod et.al.$$d2024$$iIsParent$$r$$tResilience and Charge-Dependent Fibrillation of Functional Amyloids: Interactions of Pseudomonas Biofilm-Associated FapB and FapC
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