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@ARTICLE{Han:619953,
      author       = {Han, Yuhao and Hacker, Daniela and Donders, Bronte
                      Catharina and Parperis, Christopher and Thuenauer, Roland
                      and Leterrier, Christophe and Grünewald, Kay and
                      Mikhaylova, Marina},
      title        = {{U}nveiling the cell biology of hippocampal neurons with
                      dendritic axon origin},
      journal      = {The journal of cell biology},
      volume       = {224},
      number       = {1},
      issn         = {0021-9525},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {PUBDB-2024-08044},
      pages        = {e202403141},
      year         = {2025},
      abstract     = {In mammalian axon-carrying–dendrite (AcD) neurons, the
                      axon emanates from a basal dendrite, instead of the soma, to
                      create a privileged route for action potential generation at
                      the axon initial segment (AIS). However, it is unclear how
                      such unusual morphology is established and whether the
                      structure and function of the AIS in AcD neurons are
                      preserved. By using dissociated hippocampal cultures as a
                      model, we show that the development of AcD morphology can
                      occur prior to synaptogenesis and independently of the in
                      vivo environment. A single precursor neurite first gives
                      rise to the axon and then to the AcD. The AIS possesses a
                      similar cytoskeletal architecture as the soma-derived AIS
                      and similarly functions as a trafficking barrier to retain
                      axon-specific molecular composition. However, it does not
                      undergo homeostatic plasticity, contains lesser cisternal
                      organelles, and receives fewer inhibitory inputs. Our
                      findings reveal insights into AcD neuron biology and
                      underscore AIS structural differences based on axon onset.},
      cin          = {CSSB-LIV-KG / CSSB-CF-ALFM},
      ddc          = {570},
      cid          = {I:(DE-H253)CSSB-LIV-KG-20220525 /
                      I:(DE-H253)CSSB-CF-ALFM-20210629},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101 / EXP:(DE-H253)ALFM-20250101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39495320},
      UT           = {WOS:001347460200001},
      doi          = {10.1083/jcb.202403141},
      url          = {https://bib-pubdb1.desy.de/record/619953},
}