TY  - JOUR
AU  - Han, Yuhao
AU  - Hacker, Daniela
AU  - Donders, Bronte Catharina
AU  - Parperis, Christopher
AU  - Thuenauer, Roland
AU  - Leterrier, Christophe
AU  - Grünewald, Kay
AU  - Mikhaylova, Marina
TI  - Unveiling the cell biology of hippocampal neurons with dendritic axon origin
JO  - The journal of cell biology
VL  - 224
IS  - 1
SN  - 0021-9525
CY  - New York, NY
PB  - Rockefeller Univ. Press
M1  - PUBDB-2024-08044
SP  - e202403141
PY  - 2025
AB  - In mammalian axon-carrying–dendrite (AcD) neurons, the axon emanates from a basal dendrite, instead of the soma, to create a privileged route for action potential generation at the axon initial segment (AIS). However, it is unclear how such unusual morphology is established and whether the structure and function of the AIS in AcD neurons are preserved. By using dissociated hippocampal cultures as a model, we show that the development of AcD morphology can occur prior to synaptogenesis and independently of the in vivo environment. A single precursor neurite first gives rise to the axon and then to the AcD. The AIS possesses a similar cytoskeletal architecture as the soma-derived AIS and similarly functions as a trafficking barrier to retain axon-specific molecular composition. However, it does not undergo homeostatic plasticity, contains lesser cisternal organelles, and receives fewer inhibitory inputs. Our findings reveal insights into AcD neuron biology and underscore AIS structural differences based on axon onset.
LB  - PUB:(DE-HGF)16
C6  - pmid:39495320
UR  - <Go to ISI:>//WOS:001347460200001
DO  - DOI:10.1083/jcb.202403141
UR  - https://bib-pubdb1.desy.de/record/619953
ER  -