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@ARTICLE{DelMoralMorales:619950,
      author       = {Del Moral-Morales, Aylin and Sámano, Cynthia and
                      Ocampo-Cervantes, José Antonio and Topf, Maya and Baumbach,
                      Jan and Hernández, Jossephlyn and Torres-Arciga, Karla and
                      González-Barrios, Rodrigo and Soto-Reyes, Ernesto},
      title        = {{K}ey {P}roteins for {R}egeneration in {A}. mexicanum},
      journal      = {Scientifica},
      volume       = {2024},
      number       = {1},
      issn         = {2090-908X},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {PUBDB-2024-08041},
      pages        = {5460694},
      year         = {2024},
      abstract     = {The axolotl, known for its remarkable regenerative
                      abilities, is an excellent model for studying regenerative
                      therapies. Nevertheless, the precise molecular mechanisms
                      governing its regenerative potential remain uncertain. In
                      this study, we collected samples from axolotls of different
                      ages, including 8-year-old individuals and 8-month-old
                      juveniles, obtaining their blastemas 10 days after
                      amputation. Subsequently, we conducted a transcriptomic
                      analysis comparing our samples to a set of previously
                      published experiments. Our analysis unveiled a distinctive
                      transcriptional response in the blastema, characterized by
                      differential gene expression associated with processes such
                      as bone and tissue remodeling, transcriptional regulation,
                      angiogenesis, and intercellular communication. To gain
                      deeper insights, we compared these findings with those from
                      aged axolotls that showed no signs of regeneration 10 days
                      after amputation. We identified four genes—FSTL1,
                      ADAMTS17, GPX7, and CTHRC1—that showed higher expression
                      in regenerating tissue compared to aged axolotls. Further
                      scrutiny, including structural and homology analysis,
                      revealed that these genes are conserved across vertebrate
                      species. Our discoveries point to a group of proteins
                      relevant to tissue regeneration, with their conservation in
                      vertebrates suggesting critical roles in development. These
                      findings also propose a novel gene set involved in axolotl
                      regeneration, laying a promising foundation for future
                      investigations across vertebrates.},
      cin          = {CSSB-LIV/UKE-MT},
      ddc          = {610},
      cid          = {$I:(DE-H253)CSSB-LIV_UKE-MT-20220525$},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39575453},
      UT           = {WOS:001361770300001},
      doi          = {10.1155/2024/5460694},
      url          = {https://bib-pubdb1.desy.de/record/619950},
}