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@ARTICLE{Kuzikov:614235,
      author       = {Kuzikov, Maria and Reinshagen, Jeanette and Wycisk,
                      Krzysztof and Corona, Angela and Esposito, Francesca and
                      Malune, Paolo and Manelfi, Candida and Iaconis, Daniela and
                      Beccari, Andrea and Tramontano, Enzo and Nowotny, Marcin and
                      Windshügel, Björn and Gribbon, Philip and Zaliani, Andrea},
      title        = {{D}rug repurposing screen to identify inhibitors of the
                      {RNA} polymerase (nsp12) and helicase (nsp13) from
                      {SARS}-{C}o{V}-2 replication and transcription complex},
      journal      = {Virus research / Supplement},
      volume       = {343},
      issn         = {0168-1702},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2024-05775},
      pages        = {199356},
      year         = {2024},
      note         = {ISSN 0168-1702 not unique: **2 hits**.},
      abstract     = {Coronaviruses contain one of the largest genomes among the
                      RNA viruses, coding for 14–16 non-structural proteins
                      (nsp) that are involved in proteolytic processing, genome
                      replication and transcription, and four structural proteins
                      that build the core of the mature virion. Due to
                      conservation across coronaviruses, nsps form a group of
                      promising drug targets as their inhibition directly affects
                      viral replication and, therefore, progression of infection.
                      A minimal but fully functional replication and transcription
                      complex was shown to be formed by one RNA-dependent RNA
                      polymerase (nsp12), one nsp7, two nsp8 accessory subunits,
                      and two helicase (nsp13) enzymes. Our approach involved,
                      targeting nsp12 and nsp13 to allow multiple starting point
                      to interfere with virus infection progression. Here we
                      report a combined in-vitro repurposing screening approach,
                      identifying new and confirming reported SARS-CoV-2 nsp12 and
                      nsp13 inhibitors.},
      cin          = {CSSB-CF-SPC},
      ddc          = {610},
      cid          = {I:(DE-H253)CSSB-CF-SPC-20210520},
      pnm          = {899 - ohne Topic (POF4-899) / BY-COVID - Beyond COVID
                      (101046203) / EXSCALATE4CoV - EXaSCale smArt pLatform
                      Against paThogEns for Corona Virus (101003551)},
      pid          = {G:(DE-HGF)POF4-899 / G:(EU-Grant)101046203 /
                      G:(EU-Grant)101003551},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38490582},
      UT           = {WOS:001214419000001},
      doi          = {10.1016/j.virusres.2024.199356},
      url          = {https://bib-pubdb1.desy.de/record/614235},
}