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000613885 1001_ $$00009-0008-4202-076X$$aLiu, Jiasui$$b0
000613885 245__ $$aThe palisade layer of the poxvirus core is composed of flexible A10 trimers
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000613885 520__ $$aDue to its asymmetric shape, size and compactness, the structure of the infectious mature virus (MV) of vaccinia virus (VACV), the best-studied poxvirus, remains poorly understood. Instead, subviral particles, in particular membrane-free viral cores, have been studied with cryo-electron microscopy. Here, we compared viral cores obtained by detergent stripping of MVs with cores in the cellular cytoplasm, early in infection. We focused on the prominent palisade layer on the core surface, combining cryo-electron tomography, subtomogram averaging and AlphaFold2 structure prediction. We showed that the palisade is composed of densely packed trimers of the major core protein A10. Trimers display a random order and their classification indicates structural flexibility. A10 on cytoplasmic cores is organized in a similar manner, indicating that the structures obtained in vitro are physiologically relevant. We discuss our results in the context of the VACV replicative cycle, and the assembly and disassembly of the infectious MV. 
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000613885 7001_ $$0P:(DE-H253)PIP1097097$$aCorroyer-Dulmont, Simon$$b1
000613885 7001_ $$aPražák, Vojtěch$$b2
000613885 7001_ $$00000-0001-5199-5157$$aKhusainov, Iskander$$b3
000613885 7001_ $$0P:(DE-HGF)0$$aBahrami, Karola$$b4
000613885 7001_ $$00000-0002-6049-6664$$aWelsch, Sonja$$b5
000613885 7001_ $$0P:(DE-H253)PIP1085521$$aVasishtan, Daven$$b6
000613885 7001_ $$00000-0001-7686-695X$$aObarska-Kosińska, Agnieszka$$b7
000613885 7001_ $$0P:(DE-H253)PIP1088744$$aThorkelsson, Sigurdur R.$$b8
000613885 7001_ $$0P:(DE-H253)PIP1023782$$aGruenewald, Kay$$b9$$eCorresponding author$$udesy
000613885 7001_ $$0P:(DE-H253)PIP1082957$$aQuemin, Emmanuelle$$b10$$eCorresponding author
000613885 7001_ $$00000-0002-5457-4478$$aTuroňová, Beata$$b11$$eCorresponding author
000613885 7001_ $$00000-0001-8658-2977$$aLocker, Jacomina Krijnse$$b12$$eCorresponding author
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