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@ARTICLE{Kohantorabi:610951,
      author       = {Kohantorabi, Mona and Ugolotti and Sochor, Benedikt and
                      Roessler, Johannes and Wagstaffe, Michael and Meinhardt,
                      Alexander and Beck, Esko Erik and Dolling, Silvan and Blanco
                      Garcia, Miguel and Creutzburg, Marcus and Keller, Thomas F.
                      and Schwartzkopf, Matthias and Koyiloth Vayalil, Sarathlal
                      and Thünauer, Roland and Guedez, Gabriela and Loew,
                      Christian and Ebert, Gregor and Protzer and Hammerschmidt
                      and Zeidler and Roth, Stephan and Valentin, Di and Stierle,
                      Andreas and Noei, Heshmat},
      title        = {{L}ight-{I}nduced {T}ransformation of {V}irus-{L}ike
                      {P}articles on {T}i{O}$_2$},
      journal      = {ACS applied materials $\&$ interfaces},
      volume       = {16},
      number       = {28},
      issn         = {1944-8244},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PUBDB-2024-04758},
      pages        = {37275-37287},
      year         = {2024},
      note         = {L:MB},
      abstract     = {Titanium dioxide (TiO$_2$) shows significant potential as a
                      self-cleaning material to inactivate the severe acute
                      respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent
                      virus transmission. This study provides insights into the
                      impact of UV-A light on the photocatalytic inactivation of
                      adsorbed SARS-CoV-2 virus-like particles (VLPs) on a TiO$_2$
                      surface at the molecular and atomic levels. X-ray
                      photoelectron spectroscopy, combined with density functional
                      theory calculations, reveals that spike proteins can adsorb
                      on TiO$_2$ predominantly via their amine and amide
                      functional groups in their amino acids blocks. We employ
                      atomic force microscopy and grazing-incidence small-angle
                      X-ray scattering (GISAXS) to investigate the molecular-scale
                      morphological changes during the inactivation of VLPs on
                      TiO$_2$ under light irradiation. Notably, in-situ
                      measurements reveal photo-induced morphological changes of
                      VLPs, resulting in an increased particle diameters. These
                      results suggest that denaturation of structural proteins
                      induced by UV irradiation and oxidation of the virus
                      structure through photocatalytic reactions can take place on
                      TiO$_2$ surface. The in-situ GISAXS measurements under N$_2$
                      atmosphere reveal that the virus morphology remains intact
                      under UV light. This provides evidence that the presence of
                      both oxygen and UV light is necessary to initiate
                      photocatalytic reactions on the surface and subsequently
                      inactivate the adsorbed viruses. The chemical insights into
                      the virus inactivation process obtained in this study
                      contribute significantly to the development of solid
                      materials for inactivation of enveloped viruses.},
      cin          = {FS-NL / CSSB-EMBL-CL / CSSB-CF-ALFM},
      ddc          = {600},
      cid          = {I:(DE-H253)FS-NL-20120731 /
                      I:(DE-H253)CSSB-EMBL-CL-20210806 /
                      I:(DE-H253)CSSB-CF-ALFM-20210629},
      pnm          = {632 - Materials – Quantum, Complex and Functional
                      Materials (POF4-632) / 6G3 - PETRA III (DESY) (POF4-6G3) /
                      FS-Proposal: I-20211020 (I-20211020) / FS-Proposal:
                      I-20230640 (I-20230640)},
      pid          = {G:(DE-HGF)POF4-632 / G:(DE-HGF)POF4-6G3 /
                      G:(DE-H253)I-20211020 / G:(DE-H253)I-20230640},
      experiment   = {EXP:(DE-H253)Nanolab-04-20150101 /
                      EXP:(DE-H253)Nanolab-01-20150101 /
                      EXP:(DE-H253)Nanolab-02-20150101 /
                      EXP:(DE-H253)P-P03-20150101 / EXP:(DE-H253)ALFM-20250101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38959130},
      UT           = {WOS:001265525900001},
      doi          = {10.1021/acsami.4c07151},
      url          = {https://bib-pubdb1.desy.de/record/610951},
}