TY  - JOUR
AU  - Kohantorabi, Mona
AU  - Ugolotti
AU  - Sochor, Benedikt
AU  - Roessler, Johannes
AU  - Wagstaffe, Michael
AU  - Meinhardt, Alexander
AU  - Beck, Esko Erik
AU  - Dolling, Silvan
AU  - Blanco Garcia, Miguel
AU  - Creutzburg, Marcus
AU  - Keller, Thomas F.
AU  - Schwartzkopf, Matthias
AU  - Koyiloth Vayalil, Sarathlal
AU  - Thünauer, Roland
AU  - Guedez, Gabriela
AU  - Loew, Christian
AU  - Ebert, Gregor
AU  - Protzer
AU  - Hammerschmidt
AU  - Zeidler
AU  - Roth, Stephan
AU  - Valentin, Di
AU  - Stierle, Andreas
AU  - Noei, Heshmat
TI  - Light-Induced Transformation of Virus-Like Particles on TiO<sub>2</sub>
JO  - ACS applied materials & interfaces
VL  - 16
IS  - 28
SN  - 1944-8244
CY  - Washington, DC
PB  - Soc.
M1  - PUBDB-2024-04758
SP  - 37275-37287
PY  - 2024
N1  - L:MB
AB  - Titanium dioxide (TiO<sub>2</sub>) shows significant potential as a self-cleaning material to inactivate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent virus transmission. This study provides insights into the impact of UV-A light on the photocatalytic inactivation of adsorbed SARS-CoV-2 virus-like particles (VLPs) on a TiO<sub>2</sub> surface at the molecular and atomic levels. X-ray photoelectron spectroscopy, combined with density functional theory calculations, reveals that spike proteins can adsorb on TiO<sub>2</sub> predominantly via their amine and amide functional groups in their amino acids blocks. We employ atomic force microscopy and grazing-incidence small-angle X-ray scattering (GISAXS) to investigate the molecular-scale morphological changes during the inactivation of VLPs on TiO<sub>2</sub> under light irradiation. Notably, in-situ measurements reveal photo-induced morphological changes of VLPs, resulting in an increased particle diameters. These results suggest that denaturation of structural proteins induced by UV irradiation and oxidation of the virus structure through photocatalytic reactions can take place on TiO<sub>2</sub> surface. The in-situ GISAXS measurements under N<sub>2</sub> atmosphere reveal that the virus morphology remains intact under UV light. This provides evidence that the presence of both oxygen and UV light is necessary to initiate photocatalytic reactions on the surface and subsequently inactivate the adsorbed viruses. The chemical insights into the virus inactivation process obtained in this study contribute significantly to the development of solid materials for inactivation of enveloped viruses.
LB  - PUB:(DE-HGF)16
C6  - pmid:38959130
UR  - <Go to ISI:>//WOS:001265525900001
DO  - DOI:10.1021/acsami.4c07151
UR  - https://bib-pubdb1.desy.de/record/610951
ER  -