TY  - JOUR
AU  - Wanstall, Hannah
AU  - Burkart, Florian
AU  - Dinter, Hannes
AU  - Kellermeier, Max
AU  - Kuropka, Willi
AU  - Mayet, Frank
AU  - Vinatier, Thomas
AU  - Santina, Elham
AU  - Chadwick, Amy L.
AU  - Merchant, Michael J.
AU  - Henthorn, Nicholas T.
AU  - Köpke, Michael
AU  - Stacey, Blae
AU  - Jaster-Merz, Sonja Meike
AU  - Jones, Roger M.
TI  - First in vitro measurement of VHEE relative biological effectiveness (RBE) in lung and prostate cancer cells using the ARES linac at DESY
JO  - Scientific reports
VL  - 14
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - PUBDB-2024-01803
SP  - 10957
PY  - 2024
AB  - Very high energy electrons (VHEE) are a potential candidate for radiotherapy applications. Thisincludes tumours in inhomogeneous regions such as lung and prostate cancers, due to the insensitivityof VHEE to inhomogeneities. This study explores how electrons in the VHEE range can be used toperform successful in vitro radiobiological studies. The ARES (accelerator research experiment atSINBAD) facility at DESY, Hamburg, Germany was used to deliver 154 MeV electrons to both prostate(PC3) and lung (A549) cancer cells in suspension. Dose was delivered to samples with repeatability anduniformity, quantified with Gafchromic film. Cell survival in response to VHEE was measured using theclonogenic assay to determine the biological effectiveness of VHEE in cancer cells for the first timeusing this method. Equivalent experiments were performed using 300 kVp X-rays, to enable VHEEirradiated cells to be compared with conventional photons. VHEE irradiated cancer cell survival wasfitted to the linear quadratic (LQ) model (R2 = 0.96–0.97). The damage from VHEE and X-ray irradiatedcells at doses between 1.41 and 6.33 Gy are comparable, suggesting similar relative biologicaleffectiveness (RBE) between the two modalities. This suggests VHEE is as damaging as photonradiotherapy and therefore could be used to successfully damage cancer cells during radiotherapy. TheRBE of VHEE was quantified as the relative doses required for 50
LB  - PUB:(DE-HGF)16
C6  - pmid:38740830
UR  - <Go to ISI:>//WOS:001222105400049
DO  - DOI:10.1038/s41598-024-60585-7
UR  - https://bib-pubdb1.desy.de/record/607160
ER  -