000601556 001__ 601556
000601556 005__ 20250724132718.0
000601556 0247_ $$2doi$$a10.1371/journal.ppat.1011449
000601556 0247_ $$2ISSN$$a1553-7366
000601556 0247_ $$2ISSN$$a1553-7374
000601556 0247_ $$2datacite_doi$$a10.3204/PUBDB-2024-00265
000601556 0247_ $$2altmetric$$aaltmetric:150469635
000601556 0247_ $$2pmid$$apmid:37352369
000601556 0247_ $$2WOS$$aWOS:001016234800001
000601556 0247_ $$2openalex$$aopenalex:W4381839338
000601556 037__ $$aPUBDB-2024-00265
000601556 041__ $$aEnglish
000601556 082__ $$a610
000601556 1001_ $$0P:(DE-HGF)0$$aRamaprasad, Abhinay$$b0
000601556 245__ $$aA malaria parasite phospholipase facilitates efficient asexual blood stage egress
000601556 260__ $$aLawrence, Kan.$$bPLoS$$c2023
000601556 3367_ $$2DRIVER$$aarticle
000601556 3367_ $$2DataCite$$aOutput Types/Journal article
000601556 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1729250150_1213504
000601556 3367_ $$2BibTeX$$aARTICLE
000601556 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000601556 3367_ $$00$$2EndNote$$aJournal Article
000601556 520__ $$aMalaria parasite release (egress) from host red blood cells involves parasite-mediated membrane poration and rupture, thought to involve membrane-lytic effector molecules such as perforin-like proteins and/or phospholipases. With the aim of identifying these effectors, we disrupted the expression of two Plasmodium falciparum perforin-like proteins simultaneously and showed that they have no essential roles during blood stage egress. Proteomic profiling of parasite proteins discharged into the parasitophorous vacuole (PV) just prior to egress detected the presence in the PV of a lecithin:cholesterol acyltransferase (LCAT; PF3D7_0629300). Conditional ablation of LCAT resulted in abnormal egress and a reduced replication rate. Lipidomic profiles of LCAT-null parasites showed drastic changes in several phosphatidylserine and acylphosphatidylglycerol species during egress. We thus show that, in addition to its previously demonstrated role in liver stage merozoite egress, LCAT is required to facilitate efficient egress in asexual blood stage malaria parasites. 
000601556 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000601556 536__ $$0G:(EU-Grant)751865$$aMalariaEgress - Role of perforin-like proteins and phospholipases in malaria parasite egress (751865)$$c751865$$fH2020-MSCA-IF-2016$$x1
000601556 536__ $$0G:(GEPRIS)414222880$$aDFG project G:(GEPRIS)414222880 - Funktionelle Charakterisierung der Phospholipasen im Malariaerreger Plasmodium falciparum (414222880)$$c414222880$$x2
000601556 588__ $$aDataset connected to CrossRef, Journals: bib-pubdb1.desy.de
000601556 693__ $$0EXP:(DE-MLZ)NOSPEC-20140101$$5EXP:(DE-MLZ)NOSPEC-20140101$$eNo specific instrument$$x0
000601556 7001_ $$0P:(DE-H253)PIP1085756$$aBurda, Paul-Christian$$b1
000601556 7001_ $$0P:(DE-HGF)0$$aKoussis, Konstantinos$$b2
000601556 7001_ $$0P:(DE-HGF)0$$aThomas, James A.$$b3
000601556 7001_ $$0P:(DE-H253)PIP1090898$$aPietsch, Emma$$b4
000601556 7001_ $$0P:(DE-HGF)0$$aCalvani, Enrica$$b5
000601556 7001_ $$0P:(DE-HGF)0$$aHowell, Steven A.$$b6
000601556 7001_ $$0P:(DE-HGF)0$$aMacRae, James I.$$b7
000601556 7001_ $$0P:(DE-HGF)0$$aSnijders, Ambrosius P.$$b8
000601556 7001_ $$0P:(DE-H253)PIP1023784$$aGilberger, Tim-Wolf$$b9
000601556 7001_ $$0P:(DE-HGF)0$$aBlackman, Michael J.$$b10$$eCorresponding author
000601556 773__ $$0PERI:(DE-600)2205412-1$$a10.1371/journal.ppat.1011449$$gVol. 19, no. 6, p. e1011449 -$$n6$$pe1011449 $$tPLoS pathogens$$v19$$x1553-7366$$y2023
000601556 8564_ $$uhttps://bib-pubdb1.desy.de/record/601556/files/journal.ppat.1011449.pdf$$yOpenAccess
000601556 8564_ $$uhttps://bib-pubdb1.desy.de/record/601556/files/journal.ppat.1011449.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000601556 909CO $$ooai:bib-pubdb1.desy.de:601556$$pdnbdelivery$$pec_fundedresources$$pVDB$$pdriver$$popen_access$$popenaire
000601556 9101_ $$0I:(DE-H253)_CSSB-20140311$$6P:(DE-H253)PIP1085756$$aCentre for Structural Systems Biology$$b1$$kCSSB
000601556 9101_ $$0I:(DE-H253)_CSSB-20140311$$6P:(DE-H253)PIP1090898$$aCentre for Structural Systems Biology$$b4$$kCSSB
000601556 9101_ $$0I:(DE-H253)_CSSB-20140311$$6P:(DE-H253)PIP1023784$$aCentre for Structural Systems Biology$$b9$$kCSSB
000601556 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000601556 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPLOS PATHOG : 2022$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-01-04T15:23:16Z
000601556 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-01-04T15:23:16Z
000601556 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-25
000601556 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000601556 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000601556 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bPLOS PATHOG : 2022$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-10-25
000601556 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-25
000601556 9201_ $$0I:(DE-H253)CSSB-BNITM-TG-20210520$$kCSSB-BNITM-TG$$lCSSB-BNITM-TG$$x0
000601556 980__ $$ajournal
000601556 980__ $$aVDB
000601556 980__ $$aUNRESTRICTED
000601556 980__ $$aI:(DE-H253)CSSB-BNITM-TG-20210520
000601556 9801_ $$aFullTexts