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@ARTICLE{Obeng:586169,
      author       = {Obeng, Nancy and Czerwinski, Anna and Schütz, Daniel and
                      Michels, Jan and Leipert, Jan and Bansept, Florence and
                      Garcia Garcia, Maria and Schultheiß1†, Thekla and
                      Kemlein, Melinda and Fuß, Janina and Traulsen, Arne and
                      Sondermann, Holger and Tholey, Andreas and Schulenburg,
                      Hinrich},
      title        = {{B}acterial c-di-{GMP} has a key role in establishing
                      host–microbe symbiosis},
      journal      = {Nature microbiology},
      volume       = {8},
      number       = {10},
      issn         = {2058-5276},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {PUBDB-2023-03810},
      pages        = {1809 - 1819},
      year         = {2023},
      abstract     = {Most microbes evolve faster than their hosts and should
                      therefore driveevolution of host–microbe interactions.
                      However, relatively little is knownabout the characteristics
                      that define the adaptive path of microbes to
                      hostassociation. Here we identified microbial traits that
                      mediate adaptation tohosts by experimentally evolving the
                      free-living bacterium Pseudomonaslurida with the nematode
                      Caenorhabditis elegans as its host. After tenpassages, we
                      repeatedly observed the evolution of beneficial
                      host-specialistbacteria, with improved persistence in the
                      nematode being associatedwith increased biofilm formation.
                      Whole-genome sequencing revealedmutations that uniformly
                      upregulate the bacterial second messenger,cyclic diguanylate
                      (c-di-GMP). We subsequently generated mutants
                      withupregulated c-di-GMP in different Pseudomonas strains
                      and species, whichconsistently increased host association.
                      Comparison of pseudomonadgenomes from various environments
                      revealed that c-di-GMP underliesadaptation to a variety of
                      hosts, from plants to humans. This study indicatesthat
                      c-di-GMP is fundamental for establishing host association.},
      cin          = {CSSB-DESY-HS / FS-FGIP},
      ddc          = {570},
      cid          = {I:(DE-H253)CSSB-DESY-HS-20210521 /
                      I:(DE-H253)FS-FGIP-20210408},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633)},
      pid          = {G:(DE-HGF)POF4-633},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37653009},
      UT           = {WOS:001085175700002},
      doi          = {10.1038/s41564-023-01468-x},
      url          = {https://bib-pubdb1.desy.de/record/586169},
}