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000586169 1001_ $$aObeng, Nancy$$b0
000586169 245__ $$aBacterial c-di-GMP has a key role in establishing host–microbe symbiosis
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000586169 520__ $$aMost microbes evolve faster than their hosts and should therefore driveevolution of host–microbe interactions. However, relatively little is knownabout the characteristics that define the adaptive path of microbes to hostassociation. Here we identified microbial traits that mediate adaptation tohosts by experimentally evolving the free-living bacterium Pseudomonaslurida with the nematode Caenorhabditis elegans as its host. After tenpassages, we repeatedly observed the evolution of beneficial host-specialistbacteria, with improved persistence in the nematode being associatedwith increased biofilm formation. Whole-genome sequencing revealedmutations that uniformly upregulate the bacterial second messenger,cyclic diguanylate (c-di-GMP). We subsequently generated mutants withupregulated c-di-GMP in different Pseudomonas strains and species, whichconsistently increased host association. Comparison of pseudomonadgenomes from various environments revealed that c-di-GMP underliesadaptation to a variety of hosts, from plants to humans. This study indicatesthat c-di-GMP is fundamental for establishing host association.
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000586169 7001_ $$aCzerwinski, Anna$$b1
000586169 7001_ $$aSchütz, Daniel$$b2
000586169 7001_ $$aMichels, Jan$$b3
000586169 7001_ $$aLeipert, Jan$$b4
000586169 7001_ $$aBansept, Florence$$b5
000586169 7001_ $$0P:(DE-H253)PIP1093630$$aGarcia Garcia, Maria$$b6
000586169 7001_ $$0P:(DE-HGF)0$$aSchultheiß1†, Thekla$$b7
000586169 7001_ $$aKemlein, Melinda$$b8
000586169 7001_ $$aFuß, Janina$$b9
000586169 7001_ $$aTraulsen, Arne$$b10
000586169 7001_ $$0P:(DE-H253)PIP1093629$$aSondermann, Holger$$b11
000586169 7001_ $$aTholey, Andreas$$b12
000586169 7001_ $$0P:(DE-HGF)0$$aSchulenburg, Hinrich$$b13$$eCorresponding author
000586169 773__ $$0PERI:(DE-600)2845610-5$$a10.1038/s41564-023-01468-x$$gVol. 8, no. 10, p. 1809 - 1819$$n10$$p1809 - 1819$$tNature microbiology$$v8$$x2058-5276$$y2023
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