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000585114 1001_ $$0P:(DE-H253)PIP1101429$$aBanari, Amir$$b0
000585114 245__ $$aAdvancing time-resolved structural biology: latest strategies in cryo-EM and X-ray crystallography
000585114 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2025
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000585114 520__ $$aStructural biology offers a window into the functionality of molecularmachines in health and disease. A fundamental challenge lies in capturingboth the high-resolution structural details and dynamic changes that areessential for function. The high-resolution methods of X-ray crystallographyand electron cryo-microscopy (cryo-EM) are mainly used to studyensembles of static conformations but can also capture crucial dynamictransition states. Here, we review the latest strategies and advancementsin time-resolved structural biology with a focus on capturing dynamicchanges. We describe recent technology developments for time-resolvedsample preparation and delivery in the cryo-EM and X-ray fields and explorehow these technologies could mutually benefit each other to advance ourunderstanding of biology at the molecular and atomic scales.
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000585114 7001_ $$0P:(DE-H253)PIP1032102$$aSamanta, Amit Kumar$$b1
000585114 7001_ $$0P:(DE-H253)PIP1081433$$aMunke, Anna Carina$$b2
000585114 7001_ $$0P:(DE-H253)PIP1092160$$aLaugks, Tim$$b3
000585114 7001_ $$0P:(DE-H253)PIP1006443$$aBajt, Sasa$$b4
000585114 7001_ $$0P:(DE-H253)PIP1006324$$aChapman, Henry N.$$b5
000585114 7001_ $$0P:(DE-H253)PIP1023782$$aGruenewald, Kay$$b6
000585114 7001_ $$0P:(DE-H253)PIP1021412$$aMarlovits, Thomas$$b7
000585114 7001_ $$0P:(DE-H253)PIP1012175$$aKüpper, Jochen$$b8
000585114 7001_ $$0P:(DE-H253)PIP1008707$$aMaia, Filipe$$b9
000585114 7001_ $$0P:(DE-H253)PIP1012087$$aOberthür, Dominik$$b10
000585114 7001_ $$0P:(DE-H253)PIP1020921$$aSeuring, Carolin$$b11$$eCorresponding author
000585114 773__ $$0PERI:(DE-600)2163081-1$$a10.1038/s41592-025-02659-6$$gVol. 22, no. 7, p. 1420 - 1435$$n7$$p1420 - 1435$$tNature methods$$v22$$x1548-7091$$y2025
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