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001     578755
005     20250715173338.0
024 7 _ |a 10.1038/s41377-023-01176-5
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100 1 _ |a Li, Tang
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245 _ _ |a Dose-efficient Scanning Compton X-ray Microscopy
260 _ _ |a London
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520 _ _ |a The highest resolution of images of soft matter and biological materials is ultimately limited by modification of the structure, induced by the necessarily high energy of short-wavelength radiation. Imaging the inelastically scattered X-rays at a photon energy of 60 keV (0.02 nm wavelength) offers greater signal per energy transferred to the sample than coherent-scattering techniques such as phase-contrast microscopy and projection holography. We present images of dried, unstained, and unfixed biological objects obtained by scanning Compton X-ray microscopy, at a resolution of about 40 nm. This microscope was realised using novel wedged multilayer Laue lenses that were fabricated to sub-ångström precision, a new wavefront measurement scheme for hard X rays, and efficient pixel-array detectors. The doses required to form these images were as little as 0.02% of the tolerable dose and 0.05% of that needed for phase-contrast imaging at similar resolution using 12 keV photon energy. The images obtained provide a quantitative map of the projected mass density in the sample, as confirmed by imaging a silicon wedge. Based on these results, we find that it should be possible to obtain radiation damage-free images of biological samples at a resolution below 10 nm.
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700 1 _ |a Dresselhaus, Jan Lukas
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700 1 _ |a Ivanov, Nikolay
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700 1 _ |a Prasciolu, Mauro
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700 1 _ |a Fleckenstein, Holger
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700 1 _ |a Yefanov, Oleksandr
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700 1 _ |a Zhang, Wenhui
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700 1 _ |a Pennicard, David
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700 1 _ |a Gutowski, Olof
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700 1 _ |a Villanueva Perez, Pablo
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700 1 _ |a Chapman, Henry N.
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700 1 _ |a Bajt, Sasa
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773 _ _ |a 10.1038/s41377-023-01176-5
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