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@ARTICLE{Li:578755,
author = {Li, Tang and Dresselhaus, Jan Lukas and Ivanov, Nikolay and
Prasciolu, Mauro and Fleckenstein, Holger and Yefanov,
Oleksandr and Zhang, Wenhui and Pennicard, David and Dippel,
Ann-Christin and Gutowski, Olof and Villanueva Perez, Pablo
and Chapman, Henry N. and Bajt, Sasa},
title = {{D}ose-efficient {S}canning {C}ompton {X}-ray {M}icroscopy},
journal = {Light},
volume = {12},
number = {1},
issn = {2047-7538},
address = {London},
publisher = {Nature Publishing Group},
reportid = {PUBDB-2023-00953},
pages = {130},
year = {2023},
abstract = {The highest resolution of images of soft matter and
biological materials is ultimately limited by modification
of the structure, induced by the necessarily high energy of
short-wavelength radiation. Imaging the inelastically
scattered X-rays at a photon energy of 60 keV (0.02 nm
wavelength) offers greater signal per energy transferred to
the sample than coherent-scattering techniques such as
phase-contrast microscopy and projection holography. We
present images of dried, unstained, and unfixed biological
objects obtained by scanning Compton X-ray microscopy, at a
resolution of about 40 nm. This microscope was realised
using novel wedged multilayer Laue lenses that were
fabricated to sub-ångström precision, a new wavefront
measurement scheme for hard X rays, and efficient
pixel-array detectors. The doses required to form these
images were as little as $0.02\%$ of the tolerable dose and
$0.05\%$ of that needed for phase-contrast imaging at
similar resolution using 12 keV photon energy. The images
obtained provide a quantitative map of the projected mass
density in the sample, as confirmed by imaging a silicon
wedge. Based on these results, we find that it should be
possible to obtain radiation damage-free images of
biological samples at a resolution below 10 nm.},
cin = {FS-ML / CFEL-I / LUND / FS-DS / FS-PETRA-D},
ddc = {530},
cid = {I:(DE-H253)FS-ML-20120731 / I:(DE-H253)CFEL-I-20161114 /
I:(DE-H253)LUND-20191211 / I:(DE-H253)FS-DS-20120731 /
I:(DE-H253)FS-PETRA-D-20210408},
pnm = {633 - Life Sciences – Building Blocks of Life: Structure
and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)
/ DFG project 390715994 - EXC 2056: CUI: Advanced Imaging of
Matter (390715994) / DFG project 194651731 - EXC 1074:
Hamburger Zentrum für ultraschnelle Beobachtung (CUI):
Struktur, Dynamik und Kontrolle von Materie auf atomarer
Skala (194651731)},
pid = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3 /
G:(GEPRIS)390715994 / G:(GEPRIS)194651731},
experiment = {EXP:(DE-H253)P-P07-20150101},
typ = {PUB:(DE-HGF)16},
pubmed = {37248250},
UT = {WOS:000998732800001},
doi = {10.1038/s41377-023-01176-5},
url = {https://bib-pubdb1.desy.de/record/578755},
}