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000578755 1001_ $$0P:(DE-H253)PIP1094126$$aLi, Tang$$b0$$eFirst author
000578755 245__ $$aDose-efficient Scanning Compton X-ray Microscopy
000578755 260__ $$aLondon$$bNature Publishing Group$$c2023
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000578755 520__ $$aThe highest resolution of images of soft matter and biological materials is ultimately limited by modification of the structure, induced by the necessarily high energy of short-wavelength radiation. Imaging the inelastically scattered X-rays at a photon energy of 60 keV (0.02 nm wavelength) offers greater signal per energy transferred to the sample than coherent-scattering techniques such as phase-contrast microscopy and projection holography. We present images of dried, unstained, and unfixed biological objects obtained by scanning Compton X-ray microscopy, at a resolution of about 40 nm. This microscope was realised using novel wedged multilayer Laue lenses that were fabricated to sub-ångström precision, a new wavefront measurement scheme for hard X rays, and efficient pixel-array detectors. The doses required to form these images were as little as 0.02% of the tolerable dose and 0.05% of that needed for phase-contrast imaging at similar resolution using 12 keV photon energy. The images obtained provide a quantitative map of the projected mass density in the sample, as confirmed by imaging a silicon wedge. Based on these results, we find that it should be possible to obtain radiation damage-free images of biological samples at a resolution below 10 nm.
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000578755 7001_ $$0P:(DE-H253)PIP1088012$$aDresselhaus, Jan Lukas$$b1
000578755 7001_ $$0P:(DE-H253)PIP1086928$$aIvanov, Nikolay$$b2
000578755 7001_ $$0P:(DE-H253)PIP1016171$$aPrasciolu, Mauro$$b3
000578755 7001_ $$0P:(DE-H253)PIP1011659$$aFleckenstein, Holger$$b4
000578755 7001_ $$0P:(DE-H253)PIP1006155$$aYefanov, Oleksandr$$b5
000578755 7001_ $$0P:(DE-H253)PIP1097799$$aZhang, Wenhui$$b6
000578755 7001_ $$0P:(DE-H253)PIP1008603$$aPennicard, David$$b7
000578755 7001_ $$0P:(DE-H253)PIP1010723$$aDippel, Ann-Christin$$b8
000578755 7001_ $$0P:(DE-H253)PIP1007064$$aGutowski, Olof$$b9
000578755 7001_ $$0P:(DE-H253)PIP1033133$$aVillanueva Perez, Pablo$$b10
000578755 7001_ $$0P:(DE-H253)PIP1006324$$aChapman, Henry N.$$b11$$eCorresponding author
000578755 7001_ $$0P:(DE-H253)PIP1006443$$aBajt, Sasa$$b12$$eCorresponding author
000578755 773__ $$0PERI:(DE-600)2662628-7$$a10.1038/s41377-023-01176-5$$gVol. 12, no. 1, p. 130$$n1$$p130$$tLight$$v12$$x2047-7538$$y2023
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