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@ARTICLE{Holmes:482764,
      author       = {Holmes, Susannah and Kirkwood, Henry J. and Bean, Richard
                      and Giewekemeyer, Klaus and Martin, Andrew V. and
                      Hadian-Jazi, Marjan and Wiedorn, Max O. and Oberthür,
                      Dominik and Marman, Hugh and Adriano, Luigi and Al-Qudami,
                      Nasser and Bajt, Saša and Barák, Imrich and Bari, Sadia
                      and Bielecki, Johan and Brockhauser, Sandor and Coleman,
                      Mathew A. and Cruz-Mazo, Francisco and Danilevski, Cyril and
                      Dörner, Katerina and Gañán-Calvo, Alfonso M. and
                      Graceffa, Rita and Fanghor, Hans and Heymann, Michael and
                      Frank, Matthias and Kaukher, Alexander and Kim, Yoonhee and
                      Kobe, Bostjan and Knoška, Juraj and Laurus, Torsten and
                      Letrun, Romain and Maia, Luis and Messerschmidt, Marc and
                      Metz, Markus and Michelat, Thomas and Mills, Grant and
                      Molodtsov, Serguei and Monteiro, Diana C. F. and Morgan,
                      Andrew J. and Münnich, Astrid and Peña Murillo, Gisel E.
                      and Previtali, Gianpietro and Round, Adam and Sato, Tokushi
                      and Schubert, Robin and Schulz, Joachim and Shelby, Megan
                      and Seuring, Carolin and Sellberg, Jonas A. and Sikorski,
                      Marcin and Silenzi, Alessandro and Stern, Stephan and
                      Sztuk-Dambietz, Jola and Szuba, Janusz and Trebbin, Martin
                      and Vagovic, Patrick and Ve, Thomas and Weinhausen, Britta
                      and Wrona, Krzysztof and Xavier, Paul Lourdu and Xu, Chen
                      and Yefanov, Oleksandr and Nugent, Keith A. and Chapman,
                      Henry N. and Mancuso, Adrian P. and Barty, Anton and Abbey,
                      Brian and Darmanin, Connie},
      title        = {{M}egahertz pulse trains enable multi-hit serial
                      femtosecond crystallography experiments at {X}-ray free
                      electron lasers},
      journal      = {Nature Communications},
      volume       = {13},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {PUBDB-2022-04937},
      pages        = {4708},
      year         = {2022},
      abstract     = {The European X-ray Free Electron Laser (XFEL) and Linac
                      Coherent Light Source (LCLS) II are extremely intense
                      sources of X-rays capable of generating Serial Femtosecond
                      Crystallography (SFX) data at megahertz (MHz) repetition
                      rates. Previous work has shown that it is possible to use
                      consecutive X-ray pulses to collect diffraction patterns
                      from individual crystals. Here, we exploit the MHz pulse
                      structure of the European XFEL to obtain two complete
                      datasets from the same lysozyme crystal, first hit and the
                      second hit, before it exits the beam. The two datasets,
                      separated by <1 µs, yield up to 2.1 Å resolution
                      structures. Comparisons between the two structures reveal no
                      indications of radiation damage or significant changes
                      within the active site, consistent with the calculated dose
                      estimates. This demonstrates MHz SFX can be used as a tool
                      for tracking sub-microsecond structural changes in
                      individual single crystals, a technique we refer to as
                      multi-hit SFX.},
      cin          = {FS-CFEL-1 / MPSD / FS-ML / FS-BIG / CSSB-CF-CRYO /
                      $XFEL_E1_SPB/SFX$},
      ddc          = {500},
      cid          = {I:(DE-H253)FS-CFEL-1-20120731 / I:(DE-H253)MPSD-20120731 /
                      I:(DE-H253)FS-ML-20120731 / I:(DE-H253)FS-BIG-20220318 /
                      I:(DE-H253)CSSB-CF-CRYO-20210520 /
                      $I:(DE-H253)XFEL_E1_SPB_SFX-20210408$},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / DFG project 194651731 - EXC 1074:
                      Hamburger Zentrum für ultraschnelle Beobachtung (CUI):
                      Struktur, Dynamik und Kontrolle von Materie auf atomarer
                      Skala (194651731) / DFG project 390715994 - EXC 2056: CUI:
                      Advanced Imaging of Matter (390715994)},
      pid          = {G:(DE-HGF)POF4-633 / G:(GEPRIS)194651731 /
                      G:(GEPRIS)390715994},
      experiment   = {EXP:(DE-H253)XFEL-SASE1-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35953469},
      UT           = {WOS:000840107100020},
      doi          = {10.1038/s41467-022-32434-6},
      url          = {https://bib-pubdb1.desy.de/record/482764},
}