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@ARTICLE{Bartels:473961,
      author       = {Bartels, Kim and Lasitza-Male, Tanya and Hofmann, Hagen and
                      Loew, Christian},
      title        = {{S}ingle-{M}olecule {FRET} of {M}embrane {T}ransport
                      {P}roteins},
      journal      = {ChemBioChem},
      volume       = {22},
      number       = {17},
      issn         = {1439-4227},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PUBDB-2022-00379},
      pages        = {2657 - 2671},
      year         = {2021},
      abstract     = {Uncovering the structure and function of biomolecules is a
                      fundamental goal in structural biology. Membrane-embedded
                      transport proteins are ubiquitous in all kingdoms of life.
                      Despite structural flexibility, their mechanisms are
                      typically studied by ensemble biochemical methods or by
                      static high-resolution structures, which complicate a
                      detailed understanding of their dynamics. Here, we review
                      the recent progress of single molecule Förster Resonance
                      Energy Transfer (smFRET) in determining mechanisms and
                      timescales of substrate transport across membranes. These
                      studies do not only demonstrate the versatility and
                      suitability of state-of-the-art smFRET tools for studying
                      membrane transport proteins but they also highlight the
                      importance of membrane mimicking environments in preserving
                      the function of these proteins. The current achievements
                      advance our understanding of transport mechanisms and have
                      the potential to facilitate future progress in drug design.},
      cin          = {CSSB-EMBL / FS-PS / CSSB-EMBL-CL},
      ddc          = {540},
      cid          = {I:(DE-H253)CSSB-EMBL-20141216 / I:(DE-H253)FS-PS-20131107 /
                      I:(DE-H253)CSSB-EMBL-CL-20210806},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633)},
      pid          = {G:(DE-HGF)POF4-633},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33945656},
      UT           = {WOS:000652785800001},
      doi          = {10.1002/cbic.202100106},
      url          = {https://bib-pubdb1.desy.de/record/473961},
}