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| 001 | 473306 | ||
| 005 | 20250716150543.0 | ||
| 024 | 7 | _ | |a 10.3390/ijms22073691 |2 doi |
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| 100 | 1 | _ | |a Schmutzler, Oliver |0 P:(DE-H253)PIP1027798 |b 0 |
| 245 | _ | _ | |a X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples |
| 260 | _ | _ | |a Basel |c 2021 |b Molecular Diversity Preservation International |
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| 520 | _ | _ | |a Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time. |
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| 700 | 1 | _ | |a Rothkamm, Kai |0 P:(DE-H253)PIP1033154 |b 19 |e Corresponding author |
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| 773 | _ | _ | |a 10.3390/ijms22073691 |g Vol. 22, no. 7, p. 3691 - |0 PERI:(DE-600)2019364-6 |n 7 |p 3691 |t International journal of molecular sciences |v 22 |y 2021 |x 1422-0067 |
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