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@ARTICLE{Schmutzler:473306,
      author       = {Schmutzler, Oliver and Graf, Sebastian and Behm, Nils and
                      Mansour, Wael Y. and Blumendorf, Florian and Staufer,
                      Theresa and Körnig, Christian and Salah, Dina and Kang,
                      Yanan and Peters, Jan N. and Liu, Yang and Feliu, Neus and
                      Parak, Wolfgang J. and Burkhardt, Anja and Gargioni,
                      Elisabetta and Gennis, Sabrina and Chandralingam, Sharah and
                      Höeg, Finn and Maison, Wolfgang and Rothkamm, Kai and
                      Schulz, Florian and Grüner, Florian},
      title        = {{X}-ray {F}luorescence {U}ptake {M}easurement of
                      {F}unctionalized {G}old {N}anoparticles in {T}umor {C}ell
                      {M}icrosamples},
      journal      = {International journal of molecular sciences},
      volume       = {22},
      number       = {7},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {PUBDB-2021-05636},
      pages        = {3691},
      year         = {2021},
      abstract     = {Quantitative cellular in vitro nanoparticle uptake
                      measurements are possible with a large number of different
                      techniques, however, all have their respective restrictions.
                      Here, we demonstrate the application of synchrotron-based
                      X-ray fluorescence imaging (XFI) on prostate tumor cells,
                      which have internalized differently functionalized gold
                      nanoparticles. Total nanoparticle uptake on the order of a
                      few hundred picograms could be conveniently observed with
                      microsamples consisting of only a few hundreds of cells. A
                      comparison with mass spectroscopy quantification is
                      provided, experimental results are both supported and
                      sensitivity limits of this XFI approach extrapolated by
                      Monte-Carlo simulations, yielding a minimum detectable
                      nanoparticle mass of just 5 pg. This study demonstrates the
                      high sensitivity level of XFI, allowing non-destructive
                      uptake measurements with very small microsamples within just
                      seconds of irradiation time.},
      cin          = {DOOR ; HAS-User / UNI/EXP / ITT},
      ddc          = {540},
      cid          = {I:(DE-H253)HAS-User-20120731 /
                      $I:(DE-H253)UNI_EXP-20120731$ / I:(DE-H253)ITT-20160816},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)
                      / DFG project 194651731 - EXC 1074: Hamburger Zentrum für
                      ultraschnelle Beobachtung (CUI): Struktur, Dynamik und
                      Kontrolle von Materie auf atomarer Skala (194651731) / DFG
                      project 390715994 - EXC 2056: CUI: Advanced Imaging of
                      Matter (390715994)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3 /
                      G:(GEPRIS)194651731 / G:(GEPRIS)390715994},
      experiment   = {EXP:(DE-H253)P-P11-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33916283},
      UT           = {WOS:000638620000001},
      doi          = {10.3390/ijms22073691},
      url          = {https://bib-pubdb1.desy.de/record/473306},
}