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@ARTICLE{Cheng:454378,
      author       = {Cheng, Qing-di and Chung, Hsiang-Yu and Schubert, Robin and
                      Chia, Shih-Hsuan and Falke, Sven and Mudogo, Celestin Nzanzu
                      and Kärtner, Franz and Chang, Guoqing and Betzel,
                      Christian},
      title        = {{P}rotein-crystal detection with a compact multimodal
                      multiphoton microscope},
      journal      = {Communications biology},
      volume       = {3},
      number       = {1},
      issn         = {2399-3642},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {PUBDB-2021-00463},
      pages        = {569},
      year         = {2020},
      abstract     = {There is an increasing demand for rapid, effective methods
                      to identify and detect protein micro- and nano-crystal
                      suspensions for serial diffraction data collection at X-ray
                      free-electron lasers or high-intensity micro-focus
                      synchrotron radiation sources. Here, we demonstrate a
                      compact multimodal, multiphoton microscope, driven by a
                      fiber-based ultrafast laser, enabling excitation wavelengths
                      at 775 nm and 1300 nm for nonlinear optical imaging,
                      which simultaneously records second-harmonic generation,
                      third-harmonic generation and three-photon excited
                      ultraviolet fluorescence to identify and detect protein
                      crystals with high sensitivity. The instrument serves as a
                      valuable and important tool supporting sample scoring and
                      sample optimization in biomolecular crystallography, which
                      we hope will increase the capabilities and productivity of
                      serial diffraction data collection in the future.},
      cin          = {FS-CFEL-1-BMX},
      ddc          = {570},
      cid          = {I:(DE-H253)FS-CFEL-1-BMX-20210408},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / DFG project 390715994 - EXC 2056:
                      CUI: Advanced Imaging of Matter (390715994) / DFG project
                      194651731 - EXC 1074: Hamburger Zentrum für ultraschnelle
                      Beobachtung (CUI): Struktur, Dynamik und Kontrolle von
                      Materie auf atomarer Skala (194651731) / VH-VI-419 - Dynamic
                      Pathways in Multidimensional Landscapes (VH-VI-419) /
                      VH-NG-804 - Towards Laboratory-Based Ultrafast Bright EUV
                      and X-ray Sources $(2015_IVF-VH-NG-804)$ / HCJRG-201 -
                      Advanced Laser Technologies for Ultrafast Spectroscopy of
                      Quantum Materials $(2015_IFV-HCJRG-201)$},
      pid          = {G:(DE-HGF)POF4-633 / G:(GEPRIS)390715994 /
                      G:(GEPRIS)194651731 / G:(DE-HGF)VH-VI-419 /
                      $G:(DE-HGF)2015_IVF-VH-NG-804$ /
                      $G:(DE-HGF)2015_IFV-HCJRG-201$},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33051587},
      UT           = {WOS:000583301900003},
      doi          = {10.1038/s42003-020-01275-8},
      url          = {https://bib-pubdb1.desy.de/record/454378},
}