Record #443617

iNEXT-Discovery

Infrastructure for transnational access and discovery in structural biology

Coordinator	Diamond Light Source ; EATRIS ERIC ; International Institute of Molecular and Cell Biology ; ETHNIKO IDRYMA EREVNON ; Vilnius University ; Masaryk University ; AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ; Utrecht University ; EUROPEAN INFRASTRUCTURE OF OPEN SCREENING PLATFORMS FOR CHEMICAL BIOLOGY EUROPEAN RESEARCH INFRASTUCTURE CONSORTIUM (EU-OPENSCREEN ERIC) ; SYNCHROTRON SOLEIL SOCIETE CIVILE ; INSTRUCT-ERIC ; CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE ; Lunds universitet ; National Agency For New Technologies, Energy and Sustainable Economic Development ; Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine ; STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS ; Helmholtz-Zentrum Berlin für Materialien und Energie ; Universidade Nova de Lisboa ; Johann Wolfgang Goethe-Universtität Fachbereich Informatik und Mathematik Institut für Mathematik ; Aarhus University ; CNRS - Institut des Sciences Biologiques ; CONSORCIO PARA LA CONSTRUCCION EQUIPAMIENTO Y EXPLOTACION DEL LABORATORIO DE LUZ SINCROTRON ; Eötvös Loránd University ; EUROPEAN MOLECULAR BIOLOGY LABORATORY ; Leiden University ; University of Leeds
Grant period	2020-02-01 - 2024-07-31
Funding body	European Union
Call number	H2020-INFRAIA-2019-1
Grant number	871037
Identifier	G:(EU-Grant)871037

Note: Structural biology reveals the molecular architecture of life; the three-dimensional structure of biomolecules and how they interact to form complex machineries and cells. Structural biology is key to innovations in chemistry, biotechnology and medicine: new drugs, advanced vaccines, novel biomaterials, engineered enzymes for food production, a cleaner environment, and efficient biofuels. iNEXT-Discovery takes on the challenge of proactively supporting the uptake of existing tools, and the innovation of new tools, to promote scientific Discovery and translation in a range of disciplines, building on the success of the H2020 project iNEXT (infrastructure for NMR, EM and X-rays for Translational research). iNEXT-Discovery brings together a strong network of leading structural biology facilities in partnership with regional experts and ESFRI communities in medicinal chemistry, translational medicine, biological imaging, and food research, to disseminate knowledge and services. We aim to stimulate the wider uptake of structural biology across Europe, across scientific disciplines and research sectors. Significant hardware and software advances allow targeting transnational access to advanced instrumentation also to scientists without previous expertise in structural biology: uptake will be facilitated by training and thematic calls focused on new communities. Access to our instrumentation and expertise will ultimately allow European scientists to gain structural insight that can translate into innovations in the biomedical, food, biotechnological and biomaterials sectors. Our joint research activities will roll-out advances in key technologies for translational research: fragment screening for drug development, EM efficiency and capacity, NMR applications to extend structures beyond three dimensions, and integrative structural biology approaches to look at macromolecules in cells. All our activities support innovative research of both academic and industrial users.