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000441413 1001_ $$0P:(DE-H253)PIP1085756$$aBurda, Paul-Christian$$b0
000441413 245__ $$aStructure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum
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000441413 520__ $$aProteins of the lipocalin family are known to bind small hydrophobic ligands and are involved in various physiological processes ranging from lipid transport to oxidative stress responses. The genome of the malaria parasite Plasmodium falciparum contains a single protein PF3D7_0925900 with a lipocalin signature. Using crystallography and small-angle X-ray scattering, we show that the protein has a tetrameric structure of typical lipocalin monomers; hence we name it P. falciparum lipocalin (PfLCN). We show that PfLCN is expressed in the intraerythrocytic stages of the parasite and localizes to the parasitophorous and food vacuoles. Conditional knockdown of PfLCN impairs parasite development, which can be rescued by treatment with the radical scavenger Trolox or by temporal inhibition of hemoglobin digestion. This suggests a key function of PfLCN in counteracting oxidative stress-induced cell damage during multiplication of parasites within erythrocytes.
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000441413 7001_ $$0P:(DE-H253)PIP1080461$$aCrosskey, Thomas$$b1
000441413 7001_ $$0P:(DE-H253)PIP1086561$$aLauk, Katharina$$b2
000441413 7001_ $$0P:(DE-H253)PIP1090332$$aZurborg, Aimo$$b3
000441413 7001_ $$aSöhnchen, Christoph$$b4
000441413 7001_ $$0P:(DE-H253)PIP1084754$$aLiffner, Benjamin$$b5
000441413 7001_ $$0P:(DE-H253)PIP1088064$$aWilcke, Louisa$$b6
000441413 7001_ $$0P:(DE-H253)PIP1090898$$aPietsch, Emma$$b7
000441413 7001_ $$0P:(DE-H253)PIP1081588$$aStrauss, Jan$$b8
000441413 7001_ $$0P:(DE-H253)PIP1018937$$aJeffries, Cy M.$$b9
000441413 7001_ $$0P:(DE-H253)PIP1001422$$aSvergun, Dmitri I.$$b10
000441413 7001_ $$aWilson, Danny W.$$b11
000441413 7001_ $$0P:(DE-H253)PIP1001283$$aWilmanns, Matthias$$b12
000441413 7001_ $$0P:(DE-H253)PIP1023784$$aGilberger, Tim-Wolf$$b13$$eCorresponding author
000441413 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2020.107817$$gVol. 31, no. 12, p. 107817 -$$n12$$p107817 -$$tCell reports$$v31$$x2211-1247$$y2020
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