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000426351 1001_ $$0P:(DE-H253)PIP1029103$$aMehrabi, Pedram$$b0$$eCorresponding author
000426351 245__ $$aLiquid application method for time-resolved analyses by serial synchrotron crystallography
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000426351 520__ $$aWe introduce a liquid application method for time-resolved analyses (LAMA), an in situ mixing approach for serial crystallography. Picoliter-sized droplets are shot onto chip-mounted protein crystals, achieving near-full ligand occupancy within theoretical diffusion times. We demonstrate proof-of-principle binding of GlcNac to lysozyme, and resolve glucose binding and subsequent ring opening in a time-resolved study of xylose isomerase.
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000426351 7001_ $$0P:(DE-H253)PIP1019225$$aSchulz, Eike C.$$b1
000426351 7001_ $$0P:(DE-H253)PIP1026545$$aAgthe, Michael$$b2
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000426351 7001_ $$0P:(DE-H253)PIP1005932$$aSchneider, Thomas R.$$b8
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000426351 7001_ $$0P:(DE-H253)PIP1012317$$aMiller, R. J. Dwayne$$b11$$eCorresponding author
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