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000417850 1001_ $$0P:(DE-HGF)0$$aSchulz, Eike C.$$b0
000417850 245__ $$aThe hit-and-return system enables efficient time-resolved serial synchrotron crystallography
000417850 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2018
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000417850 520__ $$aWe present a ‘hit-and-return’ (HARE) method for time-resolved serial synchrotron crystallography with time resolution from milliseconds to seconds or longer. Timing delays are set mechanically, using the regular pattern in fixed-target crystallography chips and a translation stage system. Optical pump-probe experiments to capture intermediate structures of fluoroacetate dehalogenase binding to its ligand demonstrated that data can be collected at short (30 ms), medium (752 ms) and long (2,052 ms) intervals.
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000417850 7001_ $$0P:(DE-H253)PIP1029103$$aMehrabi, Pedram$$b1
000417850 7001_ $$0P:(DE-HGF)0$$aMüller-Werkmeister, Henrike M.$$b2
000417850 7001_ $$0P:(DE-H253)PIP1007800$$aTellkamp, Friedjof$$b3
000417850 7001_ $$0P:(DE-H253)PIP1027864$$aJha, Ajay$$b4
000417850 7001_ $$0P:(DE-H253)PIP1080366$$aStuart, William$$b5
000417850 7001_ $$0P:(DE-HGF)0$$aPersch, Elke$$b6
000417850 7001_ $$0P:(DE-HGF)0$$aDe Gasparo, Raoul$$b7
000417850 7001_ $$0P:(DE-HGF)0$$aDiederich, François$$b8
000417850 7001_ $$0P:(DE-H253)PIP1028306$$aPai, Emil F.$$b9$$eCorresponding author
000417850 7001_ $$0P:(DE-H253)PIP1012317$$aMiller, R. J. Dwayne$$b10$$eCorresponding author
000417850 773__ $$0PERI:(DE-600)2163081-1$$a10.1038/s41592-018-0180-2$$gVol. 15, no. 11, p. 901 - 904$$n11$$p901 - 904$$tNature methods$$v15$$x1548-7105$$y2018
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