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@ARTICLE{Obermann:329083,
      author       = {Obermann, H. and Mandelkow, E. M. and Lange, G. and
                      Mandelkow, E.},
      title        = {{M}icrotubule oscillations. {R}ole of nucleation and
                      microtubule number concentration},
      journal      = {The journal of biological chemistry},
      volume       = {265},
      number       = {8},
      issn         = {0021-9258},
      address      = {Bethesda, Md.},
      publisher    = {Soc.},
      reportid     = {PUBDB-2017-05721},
      pages        = {4382-4388},
      year         = {1990},
      note         = {HASYLAB},
      abstract     = {Microtubules are capable of performing synchronized
                      oscillations of assembly and disassembly which has been
                      explained by reaction mechanisms involving tubulin subunits,
                      oligomers, microtubules, and GTP. Here we address the
                      question of how microtubule nucleation or their number
                      concentration affects the oscillations. Assembly itself
                      requires a critical protein concentration (Cc), but
                      oscillations require in addition a critical microtubule
                      number concentration (CMT). In spontaneous assembly this can
                      be achieved with protein concentrations Cos well above the
                      critical concentration Cc because this enhances the
                      efficiency of nucleation. Seeding with microtubules can
                      either generate oscillations or suppress them, depending on
                      how the seeds alter the effective microtubule number
                      concentration. The relative influence of microtubule number
                      and total protein concentrations can be varied by the rate
                      at which assembly conditions are induced (e.g. by a
                      temperature rise): Fast T-jumps induce oscillations because
                      of efficient nucleation, slow ones do not. Oscillations
                      become damped for several reasons. One is the consumption of
                      GTP, the second is a decrease in microtubule number, and the
                      third is that the ratio of microtubules in the two phases
                      (growth-competent and shrinkage-competent) approach a steady
                      state value. This ratio can be perturbed, and the
                      oscillations restarted, by a cold shock, addition of seeds,
                      addition of GTP, or fragmentation. Each of these is
                      equivalent to a change in the effective microtubule number
                      concentration.},
      keywords     = {Macromolecular Substances (NLM Chemicals) / Microtubule
                      Proteins (NLM Chemicals) / Tubulin (NLM Chemicals) /
                      Guanosine Diphosphate (NLM Chemicals) / Guanosine
                      Triphosphate (NLM Chemicals)},
      cin          = {DESY(-2012)},
      ddc          = {570},
      cid          = {$I:(DE-H253)DESY_-2012_-20170516$},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:2307670},
      url          = {https://bib-pubdb1.desy.de/record/329083},
}