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@ARTICLE{Nogly:309582,
      author       = {Nogly, Przemyslaw and Panneels, Valerie and Nelson, Garrett
                      and Gati, Cornelius and Kimura, Tetsunari and Milne,
                      Christopher and Milathianaki, Despina and Kubo, Minoru and
                      Wu, Wenting and Conrad, Chelsie and Coe, Jesse and Bean,
                      Richard and Zhao, Yun and Båth, Petra and Dods, Robert and
                      Harimoorthy, Rajiv and Beyerlein, Kenneth and Rheinberger,
                      Jan and James, Daniel and DePonte, Daniel and Li, Chufeng
                      and Sala, Leonardo and Williams, Garth J. and Hunter, Mark
                      S. and Koglin, Jason E. and Berntsen, Peter and Nango, Eriko
                      and Iwata, So and Chapman, Henry N. and Fromme, Petra and
                      Frank, Matthias and Abela, Rafael and Boutet, Sébastien and
                      Barty, Anton and White, Thomas and Weierstall, Uwe and
                      Spence, John and Neutze, Richard and Schertler, Gebhard and
                      Standfuss, Jörg},
      title        = {{L}ipidic cubic phase injector is a viable crystal delivery
                      system for time-resolved serial crystallography},
      journal      = {Nature Communications},
      volume       = {7},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {PUBDB-2016-03927},
      pages        = {12314},
      year         = {2016},
      abstract     = {Serial femtosecond crystallography (SFX) using X-ray
                      free-electron laser sources is an emerging method with
                      considerable potential for time-resolved pump-probe
                      experiments. Here we present a lipidic cubic phase SFX
                      structure of the light-driven proton pump bacteriorhodopsin
                      (bR) to 2.3 Å resolution and a method to investigate
                      protein dynamics with modest sample requirement.
                      Time-resolved SFX (TR-SFX) with a pump-probe delay of 1 ms
                      yields difference Fourier maps compatible with the dark to M
                      state transition of bR. Importantly, the method is very
                      sample efficient and reduces sample consumption to about 1
                      mg per collected time point. Accumulation of M intermediate
                      within the crystal lattice is confirmed by time-resolved
                      visible absorption spectroscopy. This study provides an
                      important step towards characterizing the complete
                      photocycle dynamics of retinal proteins and demonstrates the
                      feasibility of a sample efficient viscous medium jet for
                      TR-SFX.},
      cin          = {FS-CFEL-1},
      ddc          = {500},
      cid          = {I:(DE-H253)FS-CFEL-1-20120731},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      NANOMEM - Membrane Protein Nanocrystallography (317079) /
                      PSI-FELLOW - International Fellowship Program on Materials
                      $\&$ Matter, Energy $\&$ Environment, Human Health $\&$
                      Life-Sciences, and Accelerator Technology (290605) /
                      VH-GS-500 - PIER Helmholtz Graduate School
                      $(2015_IFV-VH-GS-500)$},
      pid          = {G:(DE-HGF)POF3-6215 / G:(EU-Grant)317079 /
                      G:(EU-Grant)290605 / $G:(DE-HGF)2015_IFV-VH-GS-500$},
      experiment   = {EXP:(DE-H253)CFEL-Exp-20150101 /
                      EXP:(DE-MLZ)External-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000381904200001},
      pubmed       = {pmid:27545823},
      doi          = {10.1038/ncomms12314},
      url          = {https://bib-pubdb1.desy.de/record/309582},
}