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000169302 0247_ $$2ISSN$$a1471-2970
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000169302 1001_ $$0P:(DE-H253)PIP1006324$$aChapman, H. N.$$b0$$eCorresponding Author
000169302 245__ $$aDiffraction before destruction
000169302 260__ $$aLondon$$bJSTOR$$c2014
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000169302 520__ $$aX-ray free-electron lasers have opened up the possibility of structure determination of protein crystals at room temperature, free of radiation damage. The femtosecond-duration pulses of these sources enable diffraction signals to becollected from samples at doses of 1000 MGy or higher. The sample is vaporized by the intense pulse, but not before the scattering that gives rise to the diffraction pattern takes place. Consequently, only a single flash diffraction pattern can be recorded from a crystal, giving rise to the method of serial crystallography where tens of thousands of patterns are ollected from individual crystals that flow across the beam and the patterns are indexed and aggregated into a set of structure factors. The high-dose tolerance and the many-crystal averaging approach allow data to be collected from much smaller crystals than have been examined at synchrotron radiation facilities, even from radiation-sensitive samples. Here, we review the interaction of intense femtosecond X-ray pulses with materials and discuss the implications forstructure determination. We identify various dose regimes and conclude that the strongest achievable signals for a given sample are attained at the highest possible dose rates, from highest possible pulse intensities.
000169302 536__ $$0G:(DE-H253)POF2-CFEL-Exp.-20130405$$aExperiments at CFEL (POF2-544)$$cPOF2-544$$fPOF II$$x0
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000169302 7001_ $$0P:(DE-H253)PIP1011740$$aCaleman, C.$$b1
000169302 7001_ $$0P:(DE-H253)PIP1008264$$aTimneanu, N.$$b2
000169302 773__ $$0PERI:(DE-600)2012979-8$$a10.1098/rstb.2013.0313$$gVol. 369, no. 1647, p. 20130313 - 20130313$$n1647$$p20130313$$tPhilosophical transactions of the Royal Society of London / B$$v369$$x1471-2970$$y2014
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000169302 9101_ $$0I:(DE-H253)_CFEL-20120731$$6P:(DE-H253)PIP1006324$$aCentre for Free-Electron Laser Science$$b0$$k>CFEL
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000169302 9141_ $$y2014
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