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@ARTICLE{Pietralik:148178,
author = {Pietralik, Z. and Krzyszton, R. and Kida, W. and
Andrzejewska, W. and Kozak, M. and DESY},
title = {{S}tructure and {C}onformational {D}ynamics of
{DMPC}/{D}icationic {S}urfactant and {DMPC}/{D}icationic
{S}urfactant/{DNA} {S}ystems},
journal = {International journal of molecular sciences},
volume = {14},
issn = {1422-0067},
address = {Basel},
publisher = {Molecular Diversity Preservation International},
reportid = {PHPPUBDB-26216},
pages = {7642-7659},
year = {2013},
abstract = {Amphiphilic dicationic surfactants, known as gemini
surfactants, are currently studied for gene delivery
purposes. The gemini surfactant molecule is composed of two
hydrophilic "head" groups attached to hydrophobic chains and
connected via molecular linker between them. The influence
of different concentrations of 1,5-bis
(1-imidazolilo-3-decyloxymethyl) pentane chloride (gemini
surfactant) on the thermotropic phase behaviour of
1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayers
with and without the presence of DNA was investigated using
Fourier transformed infrared (FTIR) and circular dichroism
(CD) spectroscopies, small angle scattering of synchrotron
radiation and differential scanning calorimetry. With
increasing concentration of surfactant in DMPC/DNA systems,
a disappearance of pretransition and a decrease in the main
phase transition enthalpy and temperature were observed. The
increasing intensity of diffraction peaks as a function of
surfactant concentration also clearly shows the ability of
the surfactant to promote the organisation of lipid bilayers
in the multilayer lamellar phase.},
cin = {HASYLAB(-2012) / EMBL(-2012)},
ddc = {570},
cid = {$I:(DE-H253)HASYLAB_-2012_-20130307$ /
$I:(DE-H253)EMBL_-2012_-20130307$},
pnm = {PETRA Beamline P12 (POF2-54G14)},
pid = {G:(DE-H253)POF2-P12-20130405},
experiment = {EXP:(DE-H253)P-P12-20150101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:23571492},
pmc = {pmc:PMC3645708},
UT = {WOS:000318017100057},
doi = {10.3390/ijms14047642},
url = {https://bib-pubdb1.desy.de/record/148178},
}