TY  - JOUR
AU  - Pietralik, Z.
AU  - Krzyszton, R.
AU  - Kida, W.
AU  - Andrzejewska, W.
AU  - Kozak, M.
AU  - DESY
TI  - Structure and Conformational Dynamics of DMPC/Dicationic  Surfactant and DMPC/Dicationic Surfactant/DNA Systems
JO  - International journal of molecular sciences
VL  - 14
SN  - 1422-0067
CY  - Basel
PB  - Molecular Diversity Preservation International
M1  - PHPPUBDB-26216
SP  - 7642-7659
PY  - 2013
AB  - Amphiphilic dicationic surfactants, known as gemini surfactants, are currently studied for gene delivery purposes. The gemini surfactant molecule is composed of two hydrophilic "head" groups attached to hydrophobic chains and connected via molecular linker between them. The influence of different concentrations of 1,5-bis (1-imidazolilo-3-decyloxymethyl) pentane chloride (gemini surfactant) on the thermotropic phase behaviour of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayers with and without the presence of DNA was investigated using Fourier transformed infrared (FTIR) and circular dichroism (CD) spectroscopies, small angle scattering of synchrotron radiation and differential scanning calorimetry. With increasing concentration of surfactant in DMPC/DNA systems, a disappearance of pretransition and a decrease in the main phase transition enthalpy and temperature were observed. The increasing intensity of diffraction peaks as a function of surfactant concentration also clearly shows the ability of the surfactant to promote the organisation of lipid bilayers in the multilayer lamellar phase.
LB  - PUB:(DE-HGF)16
C6  - pmid:23571492
C2  - pmc:PMC3645708
UR  - <Go to ISI:>//WOS:000318017100057
DO  - DOI:10.3390/ijms14047642
UR  - https://bib-pubdb1.desy.de/record/148178
ER  -