Journal Article

The vertebrate visual cycle hinges on enzymatically converting all-trans-retinol (at-ROL) into 11-cis-retinal (11c-RAL), the chromophore that binds to opsins in photoreceptors, forming light-responsive pigments. When struck by a photon, these pigments activate the phototransduction pathway and initiate the process of vision. [...]

The initiation of allergic responses critically depends on the recognition of an allergenic epitope by the paratope of IgE antibodies. While previous structural studies have focused on recombinant fragments or engineered forms of IgE, the structure of full-length IgE in its native state remains poorly understood. [...]

RNA cis elements play pivotal roles in regulatory processes, e.g. in transcriptional and translational regulation. [...]

Atherosclerosis is the leading cause of cardiovascular diseases and remains a global health challenge. Low-density lipoproteins are crucial in atherogenesis, with plasma levels as significant independent predictors of the condition. [...]

Photosystems I (PSI) and II (PSII) are pigment–protein complexes that perform the light-driven charge separation necessary to convert solar energy into a biochemically usable form in a fundamental process called photosynthesis. Small-angle X-ray scattering provides unique structural insights into PSI and PSII in solution under near-physiological conditions. [...]

Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive disorder characterized by pleiotropic phenotypes, including pancreatic insufficiency, skeletal abnormalities, and bone marrow dysfunction. Notably, patients with SDS exhibit an increased risk of developing myelodysplastic syndrome and leukemia. [...]

In the battle against antimicrobial resistance, lantibiotics have emerged as promising new sources for antimicrobial drugs. Their exceptional stability is due to characteristic modifications termed (methyl-)lanthionine rings. [...]

In the present study, the effect of the distribution of repeated units in copolymers based on oligo(ethylene glycol) methyl ether methacrylate (A), n-butyl methacrylate (B), and di(ethylene glycol) methyl ether methacrylate (C) is reported and discussed for the first time. Several linear structures have been synthesized via group transfer polymerization, varying from statistical to gradient to block structures. [...]

This study focuses on the kinetics of light-induced mesophase transitions in lyotropic liquid crystals containing a mixture of phospho­lipids and azo­benzene amphiphiles. Lipid membranes organize in a wide range of morphologies, directly influencing their functionality and the efficiency of associated components such as proteins. [...]