OpenAccess

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2017-06-23
13:36
OpenAccess [PUBDB-2017-05996] Journal Article
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Crystallographic and SAXS studies of S -adenosyl- L -homocysteine hydrolase from Bradyrhizobium elkanii
IUCrJ 4(3), 271 - 282 (2017) [10.1107/S2052252517002433]  GO
ddc:530
S-Adenosyl-L-homocysteine hydrolase (SAHase) from the symbiotic bacterium Bradyrhizobium elkanii (BeSAHase) was crystallized in four ligand complexes with (i) mixed adenosine (Ado) and cordycepin (Cord; 3′-deoxyadenosine), (ii) adenine (Ade), (iii) Ado and (iv) mixed 2′-deoxyadenosine (2′-dAdo) and Ade. The crystal structures were solved at resolutions of 1.84, 1.95, 1.95 and 1.54 Å, respectively. [...]
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2017-06-23
11:52
OpenAccess [PUBDB-2017-05971] Journal Article
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Joint small-angle X-ray and neutron scattering data analysis of asymmetric lipid vesicles
ddc:540
Low- and high-resolution models describing the internal transbilayer structure of asymmetric lipid vesicles have been developed. These models can be used for the joint analysis of small-angle neutron and X-ray scattering data. [...]
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2017-06-23
11:50
OpenAccess [PUBDB-2017-05969] Report/Journal Article

Covariant diagrams for one-loop matching
[MCTP-16-23; DESY-16-188; arXiv:1610.00710] ddc:530
We present a diagrammatic formulation of recently-revived covariant functional approaches to one-loop matching from an ultraviolet (UV) theory to a low-energy effective field theory. Various terms following from a covariant derivative expansion (CDE) are represented by diagrams which, unlike conventional Feynman diagrams, involve gauge-covariant quantities and are thus dubbed 'covariant diagrams.' The use of covariant diagrams helps organize and simplify one-loop matching calculations, which we illustrate with examples. [...]
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2017-06-22
17:11
OpenAccess [PUBDB-2017-05903] Journal Article
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Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular NoncompactionCLINICAL PERSPECTIVE
ddc:610
Background — High throughput next-generation sequencing techniques have made whole genome sequencing accessible in clinical practice; however, the abundance of variation in the human genomes makes the identification of a disease-causing mutation on a background of benign rare variants challenging. Methods and Results — Here we combine whole genome sequencing with linkage analysis in a 3-generation family affected by cardiomyopathy with features of autosomal dominant left ventricular noncompaction cardiomyopathy. [...]
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2017-06-22
16:59
OpenAccess [PUBDB-2017-05899] Journal Article
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A small and robust active beamstop for scattering experiments on high-brilliance undulator beamlines
ddc:540
A small active in-vacuum beamstop has been developed to monitor the flux of intense third-generation synchrotron X-ray beams protecting the downstream detector from the direct beam. Standard active beamstops, where a built-in diode directly absorbs the beam, have limitations in size and lifetime. [...]
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2017-06-22
16:24
OpenAccess [PUBDB-2017-05889] Journal Article
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Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin ?6?4
ddc:570
Integrin $\alpha6^{\beta}$4 is a major component of hemidesmosomes that mediate the stable anchorage of epithelial cells to the underlying basement membrane. Integrin $\alpha6^{\beta}$4 has also been implicated in cell proliferation and migration and in carcinoma progression. [...]
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2017-06-22
16:15
OpenAccess [PUBDB-2017-05885] Journal Article
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Automated Pipeline for Purification, Biophysical and X-Ray Analysis of Biomacromolecular Solutions
ddc:000
Small angle X-ray scattering (SAXS), an increasingly popular method for structural analysis of biological macromolecules in solution, is often hampered by inherent sample polydispersity. We developed an all-in-one system combining in-line sample component separation with parallel biophysical and SAXS characterization of the separated components. [...]
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2017-06-22
15:29
OpenAccess [PUBDB-2017-05870] Journal Article
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BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments
ddc:570
Small-angle X-ray scattering (SAXS) of macromolecules in solution is in increasing demand by an ever more diverse research community, both academic and industrial. To better serve user needs, and to allow automated and high-throughput operation, a sample changer (BioSAXS Sample Changer) that is able to perform unattended measurements of up to several hundred samples per day has been developed. [...]
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2017-06-22
15:07
OpenAccess [PUBDB-2017-05860] Journal Article
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Investigating the function of F c -specific binding of IgM to P lasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting
Cellular microbiology 17(6), 819 - 831 (2015) [10.1111/cmi.12403]  GO
ddc:570
Acquired protection from Plasmodium falciparum malaria takes years to develop, probably reflecting the ability of the parasites to evade immunity. A recent example of this is the binding of the Fc region of IgM to VAR2CSA-type PfEMP1. [...]
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2017-06-22
11:16
OpenAccess [PUBDB-2017-05845] Journal Article
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Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease
ddc:570
Antibodies to the autoantigen transglutaminase 2 (TG2) are a hallmark of celiac disease. We have studied the interaction between TG2 and an anti-TG2 antibody (679-14-E06) derived from a single gut IgA plasma cell of a celiac disease patient. [...]
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