OpenAccess

Non-destructive Schottky detectors are indispensable devices widely used in experiments at heavy-ion storage rings. In particular, they can be used to accurately determine the masses and lifetimes of short-lived exotic nuclear species. [...]

Silicon strip sensors developed for the ATLAS Inner Tracker Upgrade have shown a strong dependence of the breakdown voltage on varying levels of relative humidity (RH). The solution to this humidity sensitivity has so far been to store and test the sensors in a dry environment (RH < 10 %). [...]

Ecto-5’-nucleotidase (CD73) is a potential new drug target for cancer immunotherapy. Its overexpression is associated with various aggressive cancers, including triple-negative breast cancer (TNBC) and pancreatic cancer, making it a promising target for diagnostic imaging. [...]

TBC (Tre2/Bub2/Cdc16) domain-containing proteins constitute the widespread family of GTPase-activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. [...]

Aspartate transcarbamoylase (ATC) catalyzes the committed and rate-limiting step in the pyrimidine de novo biosynthesis pathway. While previously suggested to be a potential target for antimalarial, antitubercular, and antioncologic drug discovery, we hypothesized that an existing compound library of ATC inhibitors designed from one scaffold by fragment screening against Plamodium falciparum ATC (PfATC) may also contain inhibitors of Trypanosoma cruzi ATC (TcATC). [...]

Herein, we present crystal structures of proteins adopting a fold not identified among known -solenoids in current structural databases, a Knotted Solenoid. These proteins exhibit a characteristic solenoidal architecture, closely resembling -solenoid proteins. [...]

We perform the first dedicated comparison of five hadronic codes (AM$^{3}$, ATHEνA, B13, LeHa-Paris, and LeHaMoC) that have been extensively used in modeling the spectral energy distribution (SED) of jetted active galactic nuclei. The purpose of this comparison is to identify the sources of systematic errors (e.g., implementation method of proton–photon interactions) and to quantify the expected dispersion in numerical SED models computed with the five codes. [...]

N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic messenger RNA. Dysregulation of m6A-RNA signaling has been implicated in a wide range of human diseases. [...]

Antimicrobial resistance is one of the most significant global health threats of the 21st century, demanding urgent strategies for the development of novel therapeutic approaches. Urease, a nickel-dependent enzyme absent in the human proteome, represents an attractive target for drug development because several urease-expressing bacterial pathogens play a critical role in pathogenesis. [...]

Nonstructural protein 3 (nsp3) is crucial for SARS-CoV-2 infection. It is the largest protein of the virus with roughly 2000 residues, and a major drug target. [...]