OpenAccess

ISI oder SCOPUS Publikationen mit DESY Autor sowie alle Dissertationen mit DESY Beteiligung

Non-destructive Schottky detectors are indispensable devices widely used in experiments at heavy-ion storage rings. In particular, they can be used to accurately determine the masses and lifetimes of short-lived exotic nuclear species. [...]

Silicon strip sensors developed for the ATLAS Inner Tracker Upgrade have shown a strong dependence of the breakdown voltage on varying levels of relative humidity (RH). The solution to this humidity sensitivity has so far been to store and test the sensors in a dry environment (RH < 10 %). [...]

Ecto-5’-nucleotidase (CD73) is a potential new drug target for cancer immunotherapy. Its overexpression is associated with various aggressive cancers, including triple-negative breast cancer (TNBC) and pancreatic cancer, making it a promising target for diagnostic imaging. [...]

In this thesis the electroweak production of the Z boson in association with twojets is investigated focusing on its topology via the Vector Boson Fusion (VBF)mechanism and the determination of heavy boson parton densities.The first part presents a theoretical study of the Drell–Yan and electroweak Zjj pro-duction mechanisms and their particle-level comparison, demonstrating the domi-nance of the former and motivating the definition of a VBF-enhanced phase space toisolate electroweak contributions. The impact of electroweak corrections is discussedas a motivation for introducing electroweak (heavy boson) densities [...]

TBC (Tre2/Bub2/Cdc16) domain-containing proteins constitute the widespread family of GTPase-activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. [...]

Aspartate transcarbamoylase (ATC) catalyzes the committed and rate-limiting step in the pyrimidine de novo biosynthesis pathway. While previously suggested to be a potential target for antimalarial, antitubercular, and antioncologic drug discovery, we hypothesized that an existing compound library of ATC inhibitors designed from one scaffold by fragment screening against Plamodium falciparum ATC (PfATC) may also contain inhibitors of Trypanosoma cruzi ATC (TcATC). [...]

Herein, we present crystal structures of proteins adopting a fold not identified among known -solenoids in current structural databases, a Knotted Solenoid. These proteins exhibit a characteristic solenoidal architecture, closely resembling -solenoid proteins. [...]

We perform the first dedicated comparison of five hadronic codes (AM$^{3}$, ATHEνA, B13, LeHa-Paris, and LeHaMoC) that have been extensively used in modeling the spectral energy distribution (SED) of jetted active galactic nuclei. The purpose of this comparison is to identify the sources of systematic errors (e.g., implementation method of proton–photon interactions) and to quantify the expected dispersion in numerical SED models computed with the five codes. [...]

N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic messenger RNA. Dysregulation of m6A-RNA signaling has been implicated in a wide range of human diseases. [...]