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| 001 | 97456 | ||
| 005 | 20250731113522.0 | ||
| 024 | 7 | _ | |a pmid:20599728 |2 pmid |
| 024 | 7 | _ | |a 10.1016/j.bbrc.2010.06.071 |2 doi |
| 024 | 7 | _ | |a 1090-2104 |2 ISSN |
| 024 | 7 | _ | |a 0006-291X |2 ISSN |
| 024 | 7 | _ | |a WOS:000280867400005 |2 WOS |
| 024 | 7 | _ | |a altmetric:123126834 |2 altmetric |
| 024 | 7 | _ | |a openalex:W2090218121 |2 openalex |
| 037 | _ | _ | |a PHPPUBDB-20419 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Haikarainen, T. |
| 110 | 1 | _ | |a DESY |b European Molecular Biology Laboratory |
| 245 | _ | _ | |a Structural characterization and biological implications of di-zinc binding in the ferroxidase center of Streptococcus pyogenes Dpr. |
| 260 | _ | _ | |a Orlando, Fla. |b Academic Press |c 2010 |
| 300 | _ | _ | |a 361-365 |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Journal Article |m journal |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 440 | _ | 0 | |a Biochem. Biophys. Res. Commun. |v 398 |y 3 |x 0006-291X |0 PERI:(DE-600)1461396-7 |
| 500 | _ | _ | |3 Converted on 2013-05-30 15:51 |
| 500 | _ | _ | |3 Converted on 2013-06-21 19:21 |
| 520 | _ | _ | |a Dps proteins contain a ferroxidase site that binds and oxidizes iron, thereby preventing hydroxyl radical formation by Fenton reaction. Although the involvement of a di-iron ferroxidase site has been suggested, X-ray crystal structures of various Dps members have shown either one or two iron cations with various occupancies despite the high structural conservation of the site. Similarly, structural studies with zinc, a redox-stable replacement for iron, have shown the binding of either one or two zinc ions. Here, the crystal structure of Streptococcus pyogenes Dpr in complex with zinc reveals the binding of two zinc cations in the ferroxidase center and an additional zinc-binding site at the surface of the protein. The results suggest a structural basis for the protection of Streptococcus pyogenes in zinc stress conditions and provide a clear evidence for a di-zinc and di-iron ferroxidase site in Streptococcus pyogenes Dpr protein. |
| 536 | _ | _ | |0 G:(DE-H253)POF2-K1.2-20130405 |f POF II |x 0 |c POF2-54G13 |a DORIS Beamline K1.2 (POF2-54G13) |
| 588 | _ | _ | |a Dataset connected to Pubmed |
| 650 | _ | 2 | |2 MeSH |a Bacterial Proteins: chemistry |
| 650 | _ | 2 | |2 MeSH |a Bacterial Proteins: genetics |
| 650 | _ | 2 | |2 MeSH |a Binding Sites |
| 650 | _ | 2 | |2 MeSH |a Ceruloplasmin: chemistry |
| 650 | _ | 2 | |2 MeSH |a Ceruloplasmin: genetics |
| 650 | _ | 2 | |2 MeSH |a Crystallography, X-Ray |
| 650 | _ | 2 | |2 MeSH |a DNA-Binding Proteins: chemistry |
| 650 | _ | 2 | |2 MeSH |a DNA-Binding Proteins: genetics |
| 650 | _ | 2 | |2 MeSH |a Protein Conformation |
| 650 | _ | 2 | |2 MeSH |a Streptococcus pyogenes: enzymology |
| 650 | _ | 2 | |2 MeSH |a Zinc: chemistry |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Bacterial Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a DNA-Binding Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Dpr protein, Streptococcus |
| 650 | _ | 7 | |0 7440-66-6 |2 NLM Chemicals |a Zinc |
| 650 | _ | 7 | |0 EC 1.16.3.1 |2 NLM Chemicals |a Ceruloplasmin |
| 693 | _ | _ | |a DORIS III |f DORIS Beamline K1.2 |1 EXP:(DE-H253)DORISIII-20150101 |0 EXP:(DE-H253)D-K1.2-20150101 |6 EXP:(DE-H253)D-K1.2-20150101 |x 0 |
| 700 | 1 | _ | |a Papageorgiou, A. C. |
| 700 | 1 | _ | |a Tsoub, C.-C. |
| 700 | 1 | _ | |a Wub, J.-J. |
| 773 | _ | _ | |0 PERI:(DE-600)1461396-7 |a 10.1016/j.bbrc.2010.06.071 |g Vol. 398, p. 361-365 |p 361-365 |q 398<361-365 |t Biochemical and biophysical research communications |v 398 |x 0006-291X |y 2010 |
| 856 | 4 | 0 | |u http://www.ncbi.nlm.nih.gov/pubmed/20599728 |
| 909 | C | O | |o oai:bib-pubdb1.desy.de:97456 |p VDB |
| 910 | 1 | _ | |0 I:(DE-HGF)0 |a Externes Institut |k Extern |
| 913 | 1 | _ | |0 G:(DE-HGF)POF2-54G13 |1 G:(DE-HGF)POF2-540 |2 G:(DE-HGF)POF2-500 |9 G:(DE-H253)POF2-K1.2-20130405 |b Struktur der Materie |v DORIS III |x 0 |a DE-H253 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF2 |l Forschung mit Photonen, Neutronen, Ionen |
| 914 | 1 | _ | |y 2010 |
| 915 | _ | _ | |a JCR/ISI refereed |0 StatID:(DE-HGF)0010 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a No Author Disambiguation |0 StatID:(DE-HGF)1 |2 StatID |
| 920 | _ | 1 | |k EMBL |i European Molecular Biology Laboratory |
| 920 | 1 | _ | |0 I:(DE-H253)EMBL_-2012_-20130307 |k EMBL |l European Molecular Biology Laboratory |x 0 |
| 920 | _ | _ | |k 001 |
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