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| Home > Publications database > Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). > print |
| 001 | 97339 | ||
| 005 | 20250731113521.0 | ||
| 024 | 7 | _ | |a pmid:20965620 |2 pmid |
| 024 | 7 | _ | |a 10.1016/j.ejmech.2010.09.057 |2 doi |
| 024 | 7 | _ | |a 1768-3254 |2 ISSN |
| 024 | 7 | _ | |a 0223-5234 |2 ISSN |
| 024 | 7 | _ | |a WOS:000285485000044 |2 WOS |
| 024 | 7 | _ | |a openalex:W2060859685 |2 openalex |
| 037 | _ | _ | |a PHPPUBDB-20356 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Attolino, E. |
| 110 | 1 | _ | |a DESY |b European Molecular Biology Laboratory |
| 245 | _ | _ | |a Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). |
| 260 | _ | _ | |a Amsterdam [u.a.] |b Elsevier Science |c 2010 |
| 300 | _ | _ | |a 5919-5925 |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Journal Article |m journal |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 440 | _ | 0 | |a Eur. J. Med. Chem. |v 45 |y 12 |x 0223-5234 |0 PERI:(DE-600)2005170-0 |
| 500 | _ | _ | |3 Converted on 2013-05-30 15:49 |
| 500 | _ | _ | |3 Converted on 2013-06-21 19:21 |
| 520 | _ | _ | |a N-arylsulfonyl-based MMPs inhibitors (MMPIs) are among the most prominent inhibitors possessing nanomolar affinity. However, their poor bioavailability remains critical for the drug development of this family of molecules. The structural analysis of the complex of NNGH (the most representative member of the family) with MMP-12 provided us with the basis to effectively design simple NNGH analogues with enhanced solubility in water. Following this approach, the sec-butyl residue, not directly involved in the binding with MMP, has been replaced with hydrophilic residues thus yielding new potent inhibitors soluble in water. |
| 536 | _ | _ | |0 G:(DE-H253)POF2-No-Ref-20130405 |f POF II |x 0 |c POF2-544 |a FS Beamline without reference (POF2-544) |
| 588 | _ | _ | |a Dataset connected to Pubmed |
| 650 | _ | 2 | |2 MeSH |a Crystallography, X-Ray |
| 650 | _ | 2 | |2 MeSH |a Matrix Metalloproteinase Inhibitors |
| 650 | _ | 2 | |2 MeSH |a Models, Molecular |
| 650 | _ | 2 | |2 MeSH |a Molecular Structure |
| 650 | _ | 2 | |2 MeSH |a Nanostructures: chemistry |
| 650 | _ | 2 | |2 MeSH |a Protease Inhibitors: chemical synthesis |
| 650 | _ | 2 | |2 MeSH |a Protease Inhibitors: chemistry |
| 650 | _ | 2 | |2 MeSH |a Protease Inhibitors: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Solubility |
| 650 | _ | 2 | |2 MeSH |a Stereoisomerism |
| 650 | _ | 2 | |2 MeSH |a Structure-Activity Relationship |
| 650 | _ | 2 | |2 MeSH |a Sulfones: chemical synthesis |
| 650 | _ | 2 | |2 MeSH |a Sulfones: chemistry |
| 650 | _ | 2 | |2 MeSH |a Sulfones: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Water: chemistry |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Matrix Metalloproteinase Inhibitors |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Protease Inhibitors |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Sulfones |
| 650 | _ | 7 | |0 7732-18-5 |2 NLM Chemicals |a Water |
| 693 | _ | _ | |0 EXP:(DE-H253)Unknown-BL-20150101 |f Unknown DESY Beamline |x 0 |6 EXP:(DE-H253)Unknown-BL-20150101 |
| 700 | 1 | _ | |a Calderone, V. |
| 700 | 1 | _ | |a Dragoni, E. |
| 700 | 1 | _ | |a Fragai, M. |
| 700 | 1 | _ | |a Richichi, B. |
| 700 | 1 | _ | |a Luchinat, C. |
| 700 | 1 | _ | |a Nativi, C. |
| 773 | _ | _ | |0 PERI:(DE-600)2005170-0 |a 10.1016/j.ejmech.2010.09.057 |g Vol. 45, p. 5919-5925 |p 5919-5925 |q 45<5919-5925 |t European journal of medicinal chemistry |v 45 |x 0223-5234 |y 2010 |
| 856 | 4 | 0 | |u http://www.ncbi.nlm.nih.gov/pubmed/20965620 |
| 909 | C | O | |o oai:bib-pubdb1.desy.de:97339 |p VDB |
| 910 | 1 | _ | |0 I:(DE-HGF)0 |a Externes Institut |k Extern |
| 913 | 1 | _ | |0 G:(DE-HGF)POF2-544 |1 G:(DE-HGF)POF2-540 |2 G:(DE-HGF)POF2-500 |9 G:(DE-H253)POF2-No-Ref-20130405 |b Struktur der Materie |v In-house Research with PNI |x 0 |a DE-H253 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF2 |l Forschung mit Photonen, Neutronen, Ionen |
| 914 | 1 | _ | |y 2010 |
| 915 | _ | _ | |a JCR/ISI refereed |0 StatID:(DE-HGF)0010 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a No Author Disambiguation |0 StatID:(DE-HGF)1 |2 StatID |
| 920 | _ | 1 | |k EMBL |i European Molecular Biology Laboratory |
| 920 | 1 | _ | |0 I:(DE-H253)EMBL_-2012_-20130307 |k EMBL |l European Molecular Biology Laboratory |x 0 |
| 920 | _ | _ | |k 001 |
| 980 | _ | _ | |a PHPPUBDB |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-H253)EMBL_-2012_-20130307 |
| 980 | _ | _ | |a ConvertedRecord |
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