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| 001 | 94235 | ||
| 005 | 20250731122618.0 | ||
| 024 | 7 | _ | |a pmid:19940249 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC2795549 |2 pmc |
| 024 | 7 | _ | |a 1091-6490 |2 ISSN |
| 024 | 7 | _ | |a 0027-8424 |2 ISSN |
| 024 | 7 | _ | |a 10.1073/pnas.0911789106 |2 doi |
| 024 | 7 | _ | |a WOS:000272795300022 |2 WOS |
| 024 | 7 | _ | |a altmetric:20934385 |2 altmetric |
| 024 | 7 | _ | |a openalex:W2166335706 |2 openalex |
| 037 | _ | _ | |a PHPPUBDB-12319 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 000 |
| 100 | 1 | _ | |a Cao, X. |
| 110 | 1 | _ | |a DESY |b European Molecular Biology Laboratory |
| 245 | _ | _ | |a Golgi protein FAPP2 tubulates membranes |
| 260 | _ | _ | |a Washington, DC |c 2009 |b Academy |
| 300 | _ | _ | |a 21121-21125 |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 440 | _ | 0 | |a Proc. Nat. Acad. Sci. USA |0 PERI:(DE-600)1461794-8 |v 106 |x 1091-6490 |
| 500 | _ | _ | |3 Converted on 2013-05-30 14:57 |
| 500 | _ | _ | |3 Converted on 2013-06-21 19:21 |
| 520 | _ | _ | |a The Golgi-associated four-phosphate adaptor protein 2 (FAPP2) has been shown to possess transfer activity for glucosylceramide both in vitro and in cells. We have previously shown that FAPP2 is involved in apical transport from the Golgi complex in epithelial MDCK cells. In this paper we assign an unknown activity for the protein as well as providing structural insight into protein assembly and a low-resolution envelope structure. By applying analytical ultracentrifugation and small-angle x-ray scattering, we show that FAPP2 is a dimeric protein in solution, having a curved shape 30 nm in length. The purified FAPP2 protein has the capability to form tubules from membrane sheets in vitro. This activity is dependent on the phosphoinositide-binding activity of the PH domain of FAPP2. These data suggest that FAPP2 functions directly in the formation of apical carriers in the trans-Golgi network. |
| 536 | _ | _ | |0 G:(DE-H253)POF1-No-Ref-20130405 |f POF I |x 0 |c POF1-550 |a FS Beamline without reference (POF1-550) |
| 588 | _ | _ | |a Dataset connected to Pubmed |
| 650 | _ | 7 | |a Adaptor Proteins, Signal Transducing |0 0 |2 NLM Chemicals |
| 650 | _ | 7 | |a Lipid Bilayers |0 0 |2 NLM Chemicals |
| 650 | _ | 7 | |a PLEKHA8 protein, human |0 0 |2 NLM Chemicals |
| 650 | _ | 7 | |a Phosphatidylinositols |0 0 |2 NLM Chemicals |
| 650 | _ | 7 | |a Solutions |0 0 |2 NLM Chemicals |
| 650 | _ | 2 | |a Adaptor Proteins, Signal Transducing: chemistry |2 MeSH |
| 650 | _ | 2 | |a Adaptor Proteins, Signal Transducing: metabolism |2 MeSH |
| 650 | _ | 2 | |a Adaptor Proteins, Signal Transducing: physiology |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Cell Line |2 MeSH |
| 650 | _ | 2 | |a Dogs |2 MeSH |
| 650 | _ | 2 | |a Lipid Bilayers: metabolism |2 MeSH |
| 650 | _ | 2 | |a Phosphatidylinositols: metabolism |2 MeSH |
| 650 | _ | 2 | |a Protein Binding |2 MeSH |
| 650 | _ | 2 | |a Protein Conformation |2 MeSH |
| 650 | _ | 2 | |a Protein Multimerization |2 MeSH |
| 650 | _ | 2 | |a Solutions |2 MeSH |
| 650 | _ | 2 | |a trans-Golgi Network |2 MeSH |
| 693 | _ | _ | |0 EXP:(DE-H253)Unknown-BL-20150101 |f Unknown DESY Beamline |x 0 |6 EXP:(DE-H253)Unknown-BL-20150101 |
| 700 | 1 | _ | |a Coskun, Ü. |
| 700 | 1 | _ | |a Rössle, M. |
| 700 | 1 | _ | |a Buschhorn, S. B. |
| 700 | 1 | _ | |a Grzybek, M. |
| 700 | 1 | _ | |a Dafforn, T. R. |
| 700 | 1 | _ | |a Lenoir, M. |
| 700 | 1 | _ | |a Overduin, M. |
| 700 | 1 | _ | |a Simons, K. |
| 773 | _ | _ | |a 10.1073/pnas.0911789106 |g Vol. 106, p. 21121-21125 |0 PERI:(DE-600)1461794-8 |q 106<21121-21125 |p 21121-21125 |t Proceedings of the National Academy of Sciences of the United States of America |v 106 |y 2009 |x 1091-6490 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795549 |
| 856 | 4 | _ | |u https://bib-pubdb1.desy.de/record/94235/files/Cao_et_al_PNAS_09-for%20DESY.zip |y OpenAccess |
| 909 | C | O | |o oai:bib-pubdb1.desy.de:94235 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |0 I:(DE-HGF)0 |a Externes Institut |k Extern |
| 913 | 1 | _ | |0 G:(DE-HGF)POF1-540 |v Kondensierte Materie |9 G:(DE-H253)POF1-No-Ref-20130405 |x 0 |a DE-H253 |4 G:(DE-HGF)POF |1 G:(DE-HGF)POF1-550 |3 G:(DE-HGF)POF1 |2 G:(DE-HGF)POF1-500 |b Struktur der Materie |l Großgeräte für die Forschung mit Photonen, Neutronen, Ionen |
| 914 | 1 | _ | |a (c) National Academy of Sciences. |y 2009 |
| 915 | _ | _ | |a JCR/ISI refereed |0 StatID:(DE-HGF)0010 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a No Author Disambiguation |0 StatID:(DE-HGF)1 |2 StatID |
| 920 | _ | 1 | |i European Molecular Biology Laboratory |k EMBL |
| 920 | 1 | _ | |0 I:(DE-H253)EMBL_-2012_-20130307 |k EMBL |l European Molecular Biology Laboratory |x 0 |
| 920 | _ | _ | |k 001 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a PHPPUBDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a ConvertedRecord |
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| 980 | _ | _ | |a I:(DE-H253)EMBL_-2012_-20130307 |
| 980 | 1 | _ | |a FullTexts |
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